Sapporo Medical Journal aims to distribute and expand medical data to the World as well as build a supportive and vibrant community of researchers to connect and explore ideas by publishing articles related to all fields of medicine. Sapporo Medical Journal believes that quality and ethical research. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to:
Abstract : The aims of this study was to compare effectiveness of combination therapy metformin+dipeptidyl peptidase-4 inhibitor (DPP-4i) and metformin+sulfonylurea in terms of the achievement level of the HbA1c in Indonesian type 2 diabetes mellitus patients at Hospital. This study was an cohort retrospective with primary data obtained from electronic medical record and semi structured questionnaire prospectively. Propensity score matching (PSM) was used to generate comparable cohorts to perform outcome analysis. Generalized Linear Model-Repeated Measure (GLM-RM) analysis were used to examine the effect of combination therapy on HbA1c in each observation period. Total sample of 90 outpatients with T2DM fulfill inclusion criteria and based on PSM analysis showed that intervention (60 patients) and comparator (30 patients) groups are matching. GLM-RM analysis showed that there was an effect of the two drug groups on the HbA1c level in T2DM patients. The Partial Eta Squared level indicates that the multivariate analysis carried out can explain the variation of HbA1c by 87.2%. DPP-4i produce 0.63% reduction in HbA1c level compared to sulfonylurea as add-on therapy to metformin among Indonesian T2DM patient, in baseline without covariate. This DPP-4i effectiveness is followed by a lower incidence of hypoglycemia and weight loss.
Abstract : The field of telemedicine is developing rapidly with teleneurology being one of the branch. The use of teleneurology has helped patients gain easier access to medical care. Various studies have studied the effect of teleneurology on medical care. Thus, this systematic review is created to evaluate the outcome of teleneurology usage. Literature search was performed via PubMed, Cochrane Library, ScienceDirect, Wiley Online Library, and EBSCOhost databases. Studies selected were studies that evaluated the outcome of teleneurology from inception to June 11, 2022. Five studies were selected from literature search. Three of the studies found that teleneurology helps patient gain easier access and reduction of cost usage. The studies also found that teleneurology satisfies patients’ and caregivers’ needs. Teleneurology helps with easier access to healthcare, reduction of cost in healthcare, and fulfills the needs of patients and caregivers.
Abstract : Irreducible dorsal dislocation of the interphalangeal joint of the great toe is extremely rare. Here, we report a case of a 27-year-old male patient with an open dorsal dislocation of the left great toe resulting from a twisting injury while playing football. After the affected site was washed with normal saline, manual closed reduction was performed, but it failed because of bony and soft tissue entrapment. Nevertheless, it was successfully managed by open reduction and internal fixation using Kirschner wire. In addition, the interposition of the joint capsule and hallux sesamoid was found and reduced. This case is the first to be reported in the Middle East and the first to be reported as open dislocation worldwide.
Abstract : Heterotopic ossification (HO) is a rare preventable debilitating complication of immobility. We reported 2 cases of traumatic brain injured patients who has been bedridden and subsequently develop HO at bilateral hips for case number one and at unilateral elbow for case number two. Although they had a good cognitive recovery, the HO had hinder their everyday mobility and living activity potential. The interdisciplinary medical discussion with the patients had led to surgical removal of the heterotopic ossifications in both cases. Their quality of life improved tremendously following the intervention. This article illustrates the importance of a multidisciplinary approach and knowledge of various methods in the management of multiple disabilities that can help to achieve a realistic meaningful goal for the patients.
Abstract : This study was conducted to determine the effect of oral extract of O. stamineus in the management of diabetes in normal and alloxan-induced diabetic rats. The rats were divided into four groups, with ten rats. Group A (control) consisted of normal rats that received 2 ml (10 ml/kg of body weight) of normal saline per day. In comparison, group B consisted of diabetic rats that received 1 ml (120 mg/kg of body weight) of treatment with extract of O. stamineus. On the other hand, Group C consisted of diabetic rats given 1 mL (150 mg/kg body weight) of metformin. On the other hand, Group D was made up of untreated diabetic rats who served as a negative control group. Alloxan (150 mg/kg body weight) was injected intraperitoneally into groups B, C, and D. Diabetic group B rats given O. stamineus extract had considerably lower blood glucose levels than diabetic group D rats (p = 0.05). Similarly, diabetic rats in group B consumed significantly less food and water than diabetic rats in group D (p = 0.05). After that, diabetic group B rats given O. stamineus extract had a considerable increase in body weight (p = 0.001). In conclusion, O. stamineus extract can reduce alloxan-induced hyperglycemia in diabetic rats and prevent weight loss in diabetic animals.