Sapporo Medical Journal aims to distribute and expand medical data to the World as well as build a supportive and vibrant community of researchers to connect and explore ideas by publishing articles related to all fields of medicine. Sapporo Medical Journal believes that quality and ethical research. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to:
Abstract : This study was conducted to determine the effect of oral extract of O. stamineus in the management of diabetes in normal and alloxan-induced diabetic rats. The rats were divided into four groups, with ten rats. Group A (control) consisted of normal rats that received 2 ml (10 ml/kg of body weight) of normal saline per day. In comparison, group B consisted of diabetic rats that received 1 ml (120 mg/kg of body weight) of treatment with extract of O. stamineus. On the other hand, Group C consisted of diabetic rats given 1 mL (150 mg/kg body weight) of metformin. On the other hand, Group D was made up of untreated diabetic rats who served as a negative control group. Alloxan (150 mg/kg body weight) was injected intraperitoneally into groups B, C, and D. Diabetic group B rats given O. stamineus extract had considerably lower blood glucose levels than diabetic group D rats (p = 0.05). Similarly, diabetic rats in group B consumed significantly less food and water than diabetic rats in group D (p = 0.05). After that, diabetic group B rats given O. stamineus extract had a considerable increase in body weight (p = 0.001). In conclusion, O. stamineus extract can reduce alloxan-induced hyperglycemia in diabetic rats and prevent weight loss in diabetic animals.
Abstract : ABSTRACT The prevalence of both asthma and obesity is increasing, and studies have found a correlation between these conditions. Obesity is also related to poor asthma control (Pradeepan et al., 2013). Objective: The main study objective was to identify the impact of BMI on the frequency of ER visits and length of hospitalization among asthmatic patients aged 14 or less in Makkah from 2018 to 2022. Method: This was a retrospective cross-sectional quantitative study using data collected from the hospital system. Results: This study found no significant correlation between BMI and asthma control (p = 0.935), compared to previous studies. Additionally, the correlation between BMI and frequency of hospitalization and ER visit results was not statistically significant. Finally, this study found an association between male gender and BMI as the p-value found by a Pearson Chi-squared test was less than the level of statistical significance (p < 0.05). Obesity is more prevalent in boys than in girls, and boys are also more likely to suffer from asthma. Conclusion: Asthma is a major public health disease that affects the quality of life, and one of the most important factors affecting the disease is obesity but obesity does not affect the severity of asthma as our study showed
Abstract : Musk is a biological secretion with a unique odor produced by the Moschus moschiferus Linnaeus. Although musk was used as an anti-inflammatory, antibacterial, analgesic, antipyretic, anti-ischemic, and anti-infective in Traditional Mongolian Medicine, it has not been standardized until now. This study aimed to conduct a standardization study with focus on the determination of the quality and safety parameters of musk and evaluate the antipyretic effect of the musk by yeast-induced model of fever. The musk was extracted from the domesticated musk deer from the Musk Deer Breeding Center of the ITMT was used in this study. The content of the muscone in the natural musk was determined by HPLC method. Mice were fevered by injecting 20 mg/kg of Brewer’s yeast subcutaneously. Then, rectal temperature was recorded by thermometer for six (6) hours. In this study, the musk reduced the body temperature significantly after yeast injection compared to the control group (*p<0.01). Suitable conditions of HPLC revealed the presence of muscone in natural musk and the content of muscone in natural musk was determined at 0.31±0.005%. The quality and safety parameters of natural musk were determined: moisture content is at 24.88±0.85%, total ash at 2.62 ± 0.32% while aerobic microbes, yeast, and mold were not detected in the Musk. The standardization indicators of natural musk were defined and the Mongolian National Pharmacopeia Monograph’s draft for natural Musk was developed.
Abstract : Background: Controversy exist as regards the optimum treatment of pituitary adenoma as it is claimed to be spontaneously regressed. The aim of the current case report with literature review is to highlight the reality of the notion that pituitary adenomas might need no treatment nor surgical intervention due to their spontaneous regression. Methods: We presented here with a case of a 47-year-old female who undergone a strict observation and follow up for pituitary adenoma during a period of 10 years. Review of the literature took place as regards this notion. Conclusion: Pituitary adenomas may need no intervention because they may regress spontaneously. Although the data of one patient is limited it may shed the light on the problem. Further cohort series of this rare condition might be needed to properly investigate the condition.
Abstract : Spectrophotometric techniques can be used to accurately and rapidly determine the concentration of Nitazoxanide in body fluids (serum and urine) through react with diazonium salt ,which result from hydrolyze amino group of 2-Aminobenzothiazole by hydrochloric acid , to formation a precipitate a yellow-orange azo dye. Showed obeyed beers law between 50- 450 μg.mL-1, Molar absorptivity of 0.4916 x103 L mol-1/cm-1 was measured at 478 nm, . for Sandal's sensitivity 0.0132 has a limit of detection (LOD) of 2.96 μg.mL-1 and a limit of quantification (LOQ) of 9.875 μg.mL-1 . This technique has been successfully used to quantify various concentrations of Nitazoxanide in body fluids .