Sapporo Medical Journal aims to distribute and expand medical data to the World as well as build a supportive and vibrant community of researchers to connect and explore ideas by publishing articles related to all fields of medicine. Sapporo Medical Journal believes that quality and ethical research. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to:
Abstract : Background: Studies suggest Positive End Expiratory Pressure (PEEP) could affect clinical outcomes and pulmonary vascular resistance. Objective: To explore the influence of high PEEP versus low PEEP on pulmonary function and clinical outcomes in critically ill COVID-19 patients. Methods: This single-centred retrospective observational study included 107 patients admitted to a tertiary care centre in Saudi Arabia. Demographic data included age, gender, comorbidities, oxygen saturation, length of intensive care unit (ICU) stay, mechanical ventilation requirement, supplemental oxygen requirement, PEEP, peak pressure, driving pressure, and tidal volume (TV). PEEP ≥10cm H2O was considered high and <10cm H2O was considered low. Results: High PEEP was associated with higher mortality than low PEEP (82% versus 50%, p<0.05). The regression model also showed that high PEEP increases the risk of mortality (B= 0.51, R2=57%, p<0.04). PEEP was higher in patients with severe consolidation/progressive lung lesions (r=0.48). Lower PEEP related to improved outcomes (r=-0.21). Hypercapnia (r=-0.28) or higher respiratory rate (r=-0.61) and FiO2 (r- -0.24), were associated with poorer outcomes. The intercept was highly significant (p<0.05), indicating there could be other independent variables influencing discharge outcomes. Conclusion: Higher PEEP was associated with higher mortality. Driving pressure, peak pressure, and TV should be considered alongside PEEP to evaluate mortality risk in COVID-
Abstract : Purpose: The objective of this study was to.evaluate the effect of different angulations of impacted maxillary canine on root resorption of lateral incisor using cone-beam computed tomography(CBCT). Methods and material : The sample included 30 CBCTs presenting with unilateral or bilateral impacted maxillary canines were evaluated ranging in age from 15 to 30 years that were selected and collected.from the Department of Radiology Faculty of Dentistry (Suez Canal University). Canine angulation relative to the maxillary occlusal plane and adjacent lateral incisor was measured, as well as the locations of the impacted canines. Results : The results of the current study showed (58.8 %) with slight resorption, and (26.5%) with moderate resorption of lateral incisor root. Lateral incisor root resorption was more common in the apical third and palatal surface. There was a statistically significant relationship between root resorption severity and angulation of impacted maxillary canine relative to the lateral incisor. Angle.of impacted maxillary canine with occlusal plane can`t be solely relied on determining the severity of root resorption (RR). Conclusion : RR occure due to.proximity.of impacted.maxillary canine to adjacent lateral incisor .Slight RR occur most commonly at apical and palatal surface.
Abstract : This study aimed to investigate the self-perception of body image, weight perception, body satisfaction, and the use of weight loss medications among college students in Jeddah. A cross-sectional survey design was employed, with a sample of 342 college students aged 18-25. Data were collected using a self-administered online questionnaire, which assessed demographics, height, weight, self-perception of body image, weight perception, body satisfaction, and the use of weight loss medications. The results revealed that 36% of respondents were dissatisfied with their body image, with a higher prevalence of dissatisfaction among those with higher body mass indices. Self-perception of body image did not always align with actual BMI classification, indicating a gap between weight perception and actual weight status. While the majority of participants did not consider or use weight loss medications, 34% either used them or considered their use. These interventions should address the multifaceted factors contributing to body dissatisfaction, debunk misconceptions surrounding weight loss medications, and create a supportive campus culture that encourages body positivity and discourages weight-based discrimination. Future research should explore the effectiveness of various intervention strategies, examine the role of cultural and demographic factors, and investigate the impact of personality traits, peer influences, and family environment on body image perceptions and weight management
Abstract : Biofilms formed by Pseudomonas aeruginosa and Streptococcus pyogenes are associated with devastating infections specifically in immunocompromised patients. The emergence of multidrug resistance in bacteria raised the ultimate need to establish an alternative drug to eradicate biofilm infections. Malaysian stingless bee honey (Trigona) has been aroused as a potential food with antibacterial and antibiofilm activities. However, there is limited knowledge about the effect of Trigona honey on the opportunistic bacteria during the early stage development of infections. Hence, this study aimed to evaluate the devastating effect of Trigona honey on P. aeruginosa and S. pyogenes growth and biofilm formation. The minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of Trigona honey were determined by the broth dilution method. Biofilm formation assay for P. aeruginosa and S. pyogenes was conducted using microtiter plates. Degradation assay for established biofilms was determined after the tested bacteria were exposed to 20% of Trigona honey. Trigona honey showed MIC and MBC values of 20% and 25%, respectively against both bacterial strains. Trigona honey successfully degraded 45.67% and 61.94% of P. aeruginosa and S. pyogenes biofilms, respectively. In conclusion Trigona honey can be used as a topical agent to prevent and treat bacterial infections.
Abstract : Introduction: Hypercoagulability is a hallmark of coronavirus disease (COVID-19) complications, including Pulmonary Embolism and Multiple organ failure, which are the leading causes of mortality. Anticoagulant therapy is a hallmark therapy for COVID-19 patients with hypercoagulability. In this study, we used enoxaparin ovine as the anticoagulant. Methods: A retrospective cohort study was conducted among 24 patients with COVID-19 admitted to Wisma Atlet Kemayoran COVID-19 Emergency Hospital between April 2022 and October 2022. D-dimer levels were determined on an I-Chroma cs2100, and X-rays were taken with a Rotanode E7239X. Result: Analytics were calculated using SPSS ver. 21. P value were considered statistically significant at P < 0.05, and there was a correlation between the decreased D-dimer group and the targeted D-dimer group levels after enoxaparin ovine treatment. (P<0.00). Factors including vaccination (P=0.163) and comorbidity (P=0.259) did not affect enoxaparin prophylaxis. Conclusion: Enoxaparin ovine prophylaxis prevents clinical deterioration in covid-19 patients. Bleeding is expected in enoxaparin ovine prophylaxis therapy, as well as in other anticoagulant therapies. Although it has an effect in decreasing D-dimer levels, we could not conclude that it did not lack efficacy because the majority of the patients were not on an oxygen device.