Sapporo Medical Journal

Abstract : This study aimed to investigate the self-perception of body image, weight perception, body satisfaction, and the use of weight loss medications among college students in Jeddah. A cross-sectional survey design was employed, with a sample of 342 college students aged 18-25. Data were collected using a self-administered online questionnaire, which assessed demographics, height, weight, self-perception of body image, weight perception, body satisfaction, and the use of weight loss medications. The results revealed that 36% of respondents were dissatisfied with their body image, with a higher prevalence of dissatisfaction among those with higher body mass indices. Self-perception of body image did not always align with actual BMI classification, indicating a gap between weight perception and actual weight status. While the majority of participants did not consider or use weight loss medications, 34% either used them or considered their use. These interventions should address the multifaceted factors contributing to body dissatisfaction, debunk misconceptions surrounding weight loss medications, and create a supportive campus culture that encourages body positivity and discourages weight-based discrimination. Future research should explore the effectiveness of various intervention strategies, examine the role of cultural and demographic factors, and investigate the impact of personality traits, peer influences, and family environment on body image perceptions and weight management

Abstract : Biofilms formed by Pseudomonas aeruginosa and Streptococcus pyogenes are associated with devastating infections specifically in immunocompromised patients. The emergence of multidrug resistance in bacteria raised the ultimate need to establish an alternative drug to eradicate biofilm infections. Malaysian stingless bee honey (Trigona) has been aroused as a potential food with antibacterial and antibiofilm activities. However, there is limited knowledge about the effect of Trigona honey on the opportunistic bacteria during the early stage development of infections. Hence, this study aimed to evaluate the devastating effect of Trigona honey on P. aeruginosa and S. pyogenes growth and biofilm formation. The minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of Trigona honey were determined by the broth dilution method. Biofilm formation assay for P. aeruginosa and S. pyogenes was conducted using microtiter plates. Degradation assay for established biofilms was determined after the tested bacteria were exposed to 20% of Trigona honey. Trigona honey showed MIC and MBC values of 20% and 25%, respectively against both bacterial strains. Trigona honey successfully degraded 45.67% and 61.94% of P. aeruginosa and S. pyogenes biofilms, respectively. In conclusion Trigona honey can be used as a topical agent to prevent and treat bacterial infections.

Abstract : Introduction: Hypercoagulability is a hallmark of coronavirus disease (COVID-19) complications, including Pulmonary Embolism and Multiple organ failure, which are the leading causes of mortality. Anticoagulant therapy is a hallmark therapy for COVID-19 patients with hypercoagulability. In this study, we used enoxaparin ovine as the anticoagulant. Methods: A retrospective cohort study was conducted among 24 patients with COVID-19 admitted to Wisma Atlet Kemayoran COVID-19 Emergency Hospital between April 2022 and October 2022. D-dimer levels were determined on an I-Chroma cs2100, and X-rays were taken with a Rotanode E7239X. Result: Analytics were calculated using SPSS ver. 21. P value were considered statistically significant at P < 0.05, and there was a correlation between the decreased D-dimer group and the targeted D-dimer group levels after enoxaparin ovine treatment. (P<0.00). Factors including vaccination (P=0.163) and comorbidity (P=0.259) did not affect enoxaparin prophylaxis. Conclusion: Enoxaparin ovine prophylaxis prevents clinical deterioration in covid-19 patients. Bleeding is expected in enoxaparin ovine prophylaxis therapy, as well as in other anticoagulant therapies. Although it has an effect in decreasing D-dimer levels, we could not conclude that it did not lack efficacy because the majority of the patients were not on an oxygen device.

Abstract : Abstract—Introduction The chemotherapy will decrease the cellular immunity in nasopharyngeal carcinoma patient. The decrease of cellular immunity caused increasing infection event. Infection event in nasopharyngeal carcinoma inhibit the next cycle chemotherapy so the chemotherapy result become poorly. This study aimed to collect the data about cellular immunity post 3 cycle neoadjuvant chemotherapy, infection frequently and the difference decrease cellular immunity between infection group and non-infection group in advance nasopharyngeal carcinoma undergoing 3 cycle neoadjuvant chemotherapy. Methods: This research use before and after observasional eksperimental, 1 group without control in 8th floor building A RSUPN Dr. Cipto Mangunkusumo (RSCM), July – September 2015. Analyzed by bivariat by T or Mann Whitney Test. Results: There are decline cellular immunity, CD 4+ (p=0,002), CD 8+ (p=0,001). Ratio CD 4+/CD 8+ in normal. 4 subject (29,4%) undergoing pneumonia, 1 subject (5,8%) undergoing oral mucositis and pneumonia. Non infection groups CD 4+ quantity are: 524,22; 408,11; 374,78; 296,78. Infection groups CD 8+ quantity are: 361,00; 280,00; 286,00; 218,00. Infection groups CD 8+ quantity are: 225,50; 361,00; 183,50; 168,00. Conclusion: The cellular immunity are decreased after 3 cycle neoadjuvant chemotherapy. Oral Mucositis and pneumonia are most frequently infection. There are a difference decrease cellular immunity between infection group and non-infection groups.

Abstract : Aim of the study: The purpose of the present study was to assess fracture resistance of milled PEEK crowns veneered with composite compared to zirconia crowns veneered with porcelain under thermal and mechanical cyclic load. Methodology: A total of 20 veneered milled BioHPP and 20 veneered zirconia crowns were created and cemented on identical epoxy dies of prepared premolar. TCML was performed to simulate a one year period of oral service with 1200 thermal cycles (5°C/55°C) 2 min each cycle, 150000 mastication cycles at 49 N. After that the crowns were loaded to evaluate the fracture resistance. Results: Regarding to the fracture resistance test it was found that milled PEEK crowns showed the highest value (950.57 ± 123.26 N.) followed by veneered zirconia crowns (835.71 ± 245.14 N.). Statistical analysis showed non-significant difference between fracture resistance mean values (N) of the tested group Conclusions:. Fracture resistance of veneered PEEK crowns was comparable to that of zirconia veneered crowns