Sapporo Medical Journal

Abstract : Based on the data from "World Kidney Day", there are at least 1 out of 10 people around the world with a certain level of morbidity that leads to Chronic Kidney Disease (CKD). Many studies have shown that oxidative stress contributes to the progression of CKD. This study aims to compare malondialdehyde (MDA) and 8-dihydro-2-deoxyguanosine (8-OHdG) as oxidative stress markers in CKD patients who were treated with angiotensin-converting enzyme inhibitor (ACEi) or angiotensin receptor blocker (ARB) and who were not treated with both therapies. In this study, fifty-four hospitalized CKD patients were recruited randomly from three different hospitals in Surabaya, Indonesia. This study’s subjects were grouped based on their consumption of ACEi/ARB. Oxidative stress markers, MDA and 8-OHdG, were calculated using the Mann-Whitney test with a p-value<0.05. Urinary MDA in the patients receiving ACEi/ARB was lower than those who did not receive (3.75 (2.24-9.92) vs 5.16 (2.61-19.41); p=0.002). Urinary 8-OHdG in the patients receiving ACEi/ARB was lower than those who did not receive any (4.11 (0.36-20.26) vs 6.61 (1.76-31.35); p=0.028). There were positive correlations between urinary MDA and urinary creatinine (R=0,547; p=0,000) and between urinary 8-OHdG and urinary creatinine (R=0,630; p=0,000). These results implicate that ACEi/ARB administration in CKD patients is beneficial for reducing urinary oxidative stress markers.

Abstract : Counseling on the selection of contraceptive methods is a strategic intervention to improve the continuity of contraceptive use. Midwives as the largest source of contraceptive services in Indonesia have a major role in the implementation of contraceptive counseling, for the reason this article examines description of the implementation contraceptive counseling among midwives and the characteristics of acceptors receiving counseling. This study used data from Indonesia Demographic and Health Survey (IDHS) in 2017. The sample was married women who received contraceptive pill, injection, IUD, and implant services by midwives within 5 years prior to the survey, with a sample size of 9163 women. The implementation of contraceptive counseling among midwives in Indonesia is only 30%. Very few adolescence merried women received contraceptive counseling. Countraceptive counseling increased with education, socioeconomic level and living in urban areas. Increasing the age of marriage, access to the education right and a socio-economic level that is evenly distributed throughout the region was important points as input for policy makers in Indonesia.

Abstract : The phytochemical analysis of different parts of Melia azedarach showed that the plant contained alkaloids, carbohydrates, fixed oil and fats, protein and amino acids, saponins, sterols, triterpenoids, esters, thiols, cynogenic glycosides, tannins, flavonoids and phenolic compounds. The pharmacological studies revealed that Melia azedarach possessed antimicrobial, antiparasitic, anticancer, antioxidant, antiinflammatory, analgesic, antipyretic, reproductive, hepatoprotective, dermatological, antidiabetic, immunological, antilithiatic, hypolipidemic, butyrylcholinesterase inhibitory activity and melanogenesis stimulation effects. The current review highlighted the constituents, pharmacological and toxicological effects of Melia azedarach.

Abstract : Vulnerable groups, such as pregnant women, are a group that is at risk of health problems during a disaster. Weak physical condition due to the impact of the disaster and high anxiety can cause contractions that can lead to miscarriage, premature birth, and labor that is earlier than it should be. Family involvement as community empowerment, so that the family as the smallest unit can recognize as early as possible the risks, disastrous impacts of pregnant women. This research consists of three stages. Stage 1 is an exploratory study. The second stage is model development. A Disaster Response Pregnant Mother Family Empowerment Model was developed and used to increase the ability to face disasters in the context of reducing the risk of pregnant women in disaster conditions. Family mentoring uses the empowerment model for disaster response families twice with a span of one week. The third stage of the research was a quasi-experiment with pre-post test two group designs. Samples per group are 20 people. The sampling technique was the purposive sampling technique. The pre-post test was conducted to determine knowledge and attitudes, using a questionnaire, while the skills used observation. In the control group, only modules were given. The research concludes that the family empowerment model for pregnant women who respond to disasters affects increasing the ability to reduce the impact of disasters.

Abstract : Background:Vitamin D is an essential factor for body healthy especially in pregnant, deficiency of this vitamin is worldwide distributed health careincluding Middle East. The aim of the study is a determine the relationships between vitamin D concentration and some social and hematological parameters in pregnant women in Thi-Qar province/South of Iraq. Method:A comparative analytical study design was used with in Bint Al-Huda public hospital- and Al-Rahman gynecology and obstetrics private hospital /Thi-Qar-Southern of Iraq. In a period from September to November/2020, list of questionnaire includings: age, occupation, residence, miscarriage and trimester. specific investigation involving complete blood count and vitamin D level assay were done by coulter counter and immune fluorescence technique.. Results: the result showed high prevalence of vitamin D insufficiency among the women under study with no significant differences among the group (p value = 0.887), and there are no significant relation between the age, occupation and residence with the vitamin D levels under (p value ≤ 0.05), while the results reveals significant differences in Hb, PCV and MCHC between groups under (p value = 0.014, 0.003, 0.045), respectively. Also, high level of correlation was seen between vitamin D concentration and hematologic parameters (Hb, PCV,MCHC) with significance correlation (p-value < 0.001). Conclusion:the high percent of women including pregnant in Iraq suffer from vitamin D deficiency and insufficiency and the socio-economic factor play a role in this status with the high correlation between vit. D level and Hb, PCV and MCHC levels of blood, diagnosis and treatment of vit. D deficiency with adequate 25(OH)D concentrations are critical to maintain a good health care for pregnant women. More studies are required to detects others factors related to this deficiency in Iraqi populations