About

Sapporo Medical Journal

Sapporo Medical Journal is an open access, monthly, peer reviewed International Medical Journal with focuses on publishes research conducted in all fields of medical, medicine. There is no restriction on the length of research papers and reviews, although authors are encouraged to be concise. Sapporo Medical Journal is a scopus indexed International Medical Journal that wants to publish original articles, research articles, review articles with top-level work from all areas of Medicine, General Medicine, Medical Science Research and their application including Aetiology, bioengineering, biomedicine, cardiology, chiropody etc.
Sapporo Medical Journal
Sapporo Medical Journal
Sapporo Medical Journal
Sapporo Medical Journal
Sapporo Medical Journal
Sapporo Medical Journal
Sapporo Medical Journal
Sapporo Medical Journal
Sapporo Medical Journal
Sapporo Medical Journal
Sapporo Medical Journal

Sapporo Medical Journal aims to distribute and expand medical data to the World as well as build a supportive and vibrant community of researchers to connect and explore ideas by publishing articles related to all fields of medicine. Sapporo Medical Journal believes that quality and ethical research. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to:

Medicine Microbiology Biochemistry Pharmacology Pathology Forensic medicine Internal Medicine Physiology Anatomy Obstetrics and Gynecology Radiology Community Medicine Otorhinolaryngology Infectious Diseases General Surgery Cancer research Pulmonary Dermatology and Venereal diseases Orthopedics Neurology Anaesthesia Medical education Infectious Diseases and Vaccinology Neurosurgery Gastroenterology Nephrology Paediatrics Reproduction Dental Cardiology Surgery Nursing Otolaryngology Dermatology Diabetes Orthopaedics Hepatology Urology Psychology Anesthesiology Endocrinology Biotechnology Venereology ENT Psychiatry Pharmaceutical Analysis Pharmacy Pharmaceutical Chemistry Pulmonology Pharmaceutics Pharmaceutical Pharmacognosy Biopharmaceutics Phatmaceutical Technology Quality Assurance Pharmacodynamics Pharmacokinetics Drug Regulatory Industrial Pharmacy Pharmaceutical Nanotechnology Drug Design Affairs Phytochemistry Drug Delivery Systems Drug Discovery Pharmaceutical Microbiology Pharmacy Practice Hospital Pharmacy Clinical Pharmacy Pharmacogenomics Drug Metabolism Pharmacovigilance Toxicology Clinical Research Microbiology Phrmacoinformatics Life Sciences like Chemistry Epidemiology Biomedical Sciences Immunology Dentistry Oncology Biomedicine Physiotherapy Sexology Neuroscience Gynaecology Dermatoepidemiology Pharmacy and Nursing Angiology/Vascular Medicine Osteology Ophthalmology Haematology Kinesiology Critical care Medicine Pharmacognosy and Phytochemistry Clinical immunology Bariatrics Genomics and Proteomics Clinical and Hospital Pharmacy Radiobiology Cell Biology Geriatric Medicine Healthcare Services Healthcare Management Bioinformatics and Biotechnology
Paper ID : SMJ1904215504274

Abstract : The emergence of resistant Klebsiella pneumoniae assosiated with COVID-19 demonstrate a primary challenge for the antimicrobial therapy of infectious diseases and increases the incidence of mortality and morbidity. K. pneumoniae isolated from COVID-19 patients sputum with ratio (100%). All K. pneumoniae clinical isolates had 100% resistance to ceftriaxone , piperacillin (80%) , cefepime (60%) , amikacin (40%) , and meropenem =levofloxccin (20%). Bacterial isolates gave positive result for MHT, also all isolates formed ‎ β- lactamase at a rate of 100% by using spectrometry β-lactamase assay. Costunolide (38.3 %), Rutin (15.33%), Pentadecanoic acid (6.54%), Oliec acid (4.77%), and Caproic acid (3.22%) considered as major compounds in Saussurea costus were identified by GC-Mass spectrometry . The β-lactamase produced by K. pneumoniae were inhibited by Saussurea costus with a strong statistical significance at P- value : <0.001.

Paper ID : SMJ0604215504273

Abstract : BACKGROUND: The exact mineral content of deciduous 2nd molars (DSM) in prenatal, postnatal enamel and neonatal line is not fully determined. AIM: To determine the morphology and mineral content of prenatal, postnatal enamel and neonatal line. MATERIAL AND METHODS: 5 human exfoliated DSM were collected, each tooth was divided into two halves so that 10 samples were obtained. Prenatal, postnatal enamel and neonatal line were examined. Samples were assessed morphologically by light microscope (LM), stereomicroscope and Scanning electron microscope (SEM). Moreover the samples were assessed for mineral analysis and all data were statistically analyzed. RESULTS AND CONCLUSION: In DSM, Morphological study revealed that, postnatal enamel of DSM was more translucent in color than prenatal enamel in stereomicroscope. The neonatal line had chalky white appearance in stereomicroscope. SEM morphometric analysis showed an increase in surface area of postnatal enamel rods whereas, their number showed a decrease when compared to prenatal enamel. Elemental study of showed a significant increase in Calcium (Ca) and Ca/P ratio weight % and non-significant decrease in Phosphorous (P) weight % when prenatal compared to postnatal enamel and when postnatal enamel compared to neonatal line. C weight % of prenatal enamel decreased significantly when compared to postnatal enamel and decreased non-significantly when postnatal enamel was compared to neonatal line. Magnesium (Mg) and sodium (Na) weight

Paper ID : SMJ2803215503271

Abstract : Genetic and population-statistical results of association of alleles and genotypes of rs1805010 lle50Val polymorphism of IL4RA gene are analyzed, in 75 patients with atopic bronchial asthma and 25 healthy children, depending on the article, type of inheritance, homozygous or heterozygous genotype. The results of the study showed that in general the increased risk of developing allergic asthma in children is determined in carriers of homozygous genotype A/A polymorphism rs1805010 lle50Val gene IL4RA, because in patients with asthma, it occurs 4.34 times more often than in almost healthy children (OR = 6.10; 95% CI [1.33-27.93]; p <0.003), than in almost healthy children. The association of the lle50Val polymorphism of the IL4RA gene in rs1805010 with the development of bronchial asthma by us among girls has not been established, , while the homozygous genotype G / G is more common (0.368) among boys who have, accordingly, a reduced risk of developing bronchial asthma (OR = 0.34; 95% CI [0.16-0.73]; p = 0.003).

Paper ID : SMJ2703215503270
Sapporo Medical Journal
Author : Halimah, Hanifah Nuryani Lioe*, Ratu Ayu Dewi Sartika,

Abstract : Food processing with deep fat frying method with palm oil has been frequently made either by restaurants, caterings, or food industries in Indonesia. It has been identified that the frying process with high temperature and long frying duration cause of the oil damage. The objective of this review is to describe the chemical change in palm oil during the frying process with deep fat frying method and to evaluate the results of oxidation, hydrolysis, and polymerization reactions during the frying process. The frying temperature between 150-250oC, frying duration until 48-50 hours, the repeated oil use caused the decomposition of some triglycerides, the composition change of saturated fatty acids (SFA), mono-unsaturated fatty acids (MUFA), poly-unsaturated fatty acids (PUFA), and the formation of aldehyde compound, short chain fatty acids, ketone compound categorized as volatile and non-volatile compounds. The evaluation of the oil quality during the frying process taking into account the peroxide, iodine, para-anisidine, free fatty acid values and the percentage of total polar compounds is also discussed in this review. The toxic contaminant compounds due to high temperature frying (in average 180oC) have been formed. They are trans-fatty acids i.e. elaidic (C18:1,9t) and trans (C18:2,9C12t/9t12c). Glycidyl esters compound are formed in palm oil during temperature deodorization process of >230oC. The contaminant concentration reduces during the frying which are observed from so

Paper ID : SMJ0703215503268

Abstract : A spectrophotometric analysis for valuing microgram quantities of Chlorpromazine hydrochloride drug in aqueous solution is defined that is simple, fast, and sensitive. The process is based on the formation of an intense red colored substance with maximum absorption at 530 nm from a transition metal complex between Chlorpromazine hydrochloride and Lead (IV) oxide (metal) in the existence of hydrochloride acid. With a Molar absorptivity of 2.9394 x104 l.mol-1.cm-1 and a Sandells sensitivity 0.014μg.Cm-2, Beer's Law is followed over a concentration range of ( 1- 20) μg.ml-2. The planned process has been effectively useful for assessment of Chlorpromazine hydrochloride in pharmaceutical preparations (Largactil drug)and bulk drug, and The optimum conditions for all colour production are defined. In this methodology, shared excipients and additives had no effect.