Sapporo Medical Journal aims to distribute and expand medical data to the World as well as build a supportive and vibrant community of researchers to connect and explore ideas by publishing articles related to all fields of medicine. Sapporo Medical Journal believes that quality and ethical research. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to:
Abstract : Prostate cancer patients often suffer castration-resistant prostate cancer (CRPC), resulting in high mortality rates. Few is still known regarding the factors affecting survival in CRPC patients. We aimed to evaluate PSA level and time to PSA nadir as a prognostic marker for survival in CRPC patients. This is an analytical retrospective study evaluating castration-resistant prostate cancer patients’ survival. Evaluated data included sex, age, initial PSA level, final PSA level, time to PSA nadir (TTN), time to CRPC progression (TTC), and survival status. There were 24 patients with CRPC included in this study. There is a significant difference (p<0.05) of initial PSA level between surviving patients (445,7 + 165,6 ng/mL) and patients who died (200.7 + 144.9 ng/mL). The association between TTN and TTC was also significant (R=0.737, p<0.05). The differences of PSA nadir level, TTN, and TTC between the groups were insignificant (p>0.05). There is a significant difference of initial PSA between surviving and non-surviving patients, whereas no notable differences are apparent in PSA nadir level, time to PSA nadir, and time to CRPC progression. However, there is an association between the time to PSA nadir and CRPC progression.
Abstract : The study focused on the content changes of polyphenol and chlorophyll, and antioxidant activities of Centella asiatica grown in Khanh Hoa province, Vietnam according to the growth times of 30 to 120 days. Extracts from Centella asiatica were collected by using ultrasonic-assisted extraction and various antioxidant activities were evaluated such as total antioxidant activity, reducing power activity, and DPPH free radical scavenging activity. Results showed that the highest chlorophyll content of 5.104 ± 0.041 mg chlorophyll equivalent/g DW at the 45th growth day of centella. Polyphenol content and reducing power activity got the highest value at 75th growth day of Centella, corresponding to 14.156 ± 0.026 mg gallic acid equivalent/g DW and 22.891 ± 0.040 mg FeSO4 equivalent/g DW, respectively. Centella asiatica possessed the highest total antioxidant activity and DPPH free radical scavenging activity at the 60th growth day, corresponding to 6.059 ± 0.022 mg ascorbic acid equivalent/g DW and 79.49 (%), respectively. The correlation between polyphenol content and reducing power activity was higher than other correlations. Centella asiatica is useful in the production of antioxidant medicine plants applicable to functional food and pharmaceutical antioxidants.
Abstract : Background: Reactive oxygen species (ROS) show a key role in the expansion of tumors. The enzymatic and non-enzymatic antioxidant guarding systems of the cell avoid oxidant harm to various biomolecules by neutralizing produce of free radicals. Glutathione (GSH) and glutathione dependent enzymes [glutathione reductase (GR) glutathione-s-transferase (GST) and glutathione peroxidase (GPx) are the crucial bases of cellular response to oxidative stress. Glutathione acts an essential part in detoxification of carcinogens. Objectives: To assess the role of antioxidant defense an accomplished by glutathione dependent enzymes with their cofactors and comparative investigation activities of the glutathione-dependent enzymes in the blood serum and saliva in the patients with breast cancer. Materials and Methods: Serum and salivary GSH and glutathione dependent enzymes such as GPx, GST, and GR levels were assessed in 40 healthy controls and 48 females with breast cancer utilizing a spectrophotometer. Serum and salivary trace elements (zinc and selenium) were estimated by utilizing the atom absorption photometry. Results: Serum and saliva analysis displayed significantly diminished (P<0.0001) of GSH, GST, GR and GPx activities in breast cancer patients compared to control group. The mean levels of serum and salivary trace elements (zinc and selenium) were significantly reduced (<0.001) in breast cancer patients as compared to levels of healthy controls. Conclusion: Serum and salivary an
Abstract : Background: Preeclampsia is still the main cause of maternal death in Indonesia. Pregnancy care, commonly called Antenatal Care (ANC) is a strategic effort to detect preeclampsia symptoms early, for that ANC must be carried out according to standards. Antenatal care standard consisted of measurements: weight, height, blood pressure, arm circumference, symphysis-fundal height, fetal presentation and fetal heart rate, tetanus toxoid immunization, blood supplement tablets, laboratory tests, case management and interview sessions (counseling), shortened to 10T. Objective: This study measured proportion of antenatal care were in accordance with the standards, how many were diagnosed with preeclampsia and whether standard of antenatal care associated with preeclampsia. Methods: This study used data from Analysis of Indonesian Demographic And Health Surveys (IDHS) 2017. The subjects in this study were women who gave birth last live birth in the 5 years prior to the survey, with 15.021 respondents. Data analysis used multiple logistic regression. Results: 21.5% of pregnant women who received antenatal care according to the standards and 3% who detected preeclampsia. Implement antenatal care standards could detect preeclampsia better than antenatal care unstandardized with an OR of 1.8 (CI= 1.5-2.2).
Abstract : Abstract - In order to preserve sound maternal health, nutrition plays a significant and definite role in the course of pregnancy. This study was aimed to analyze the effect of giving instant papeda with laor powder (Eunice viridis) on the increase in weight pregnant rats and birth weight. An experimental study with Randomized Controlled Trial Post Test Design was performed towards 24 pregnant rat categorized into 4 groups as follows: Control Group (K), Group P1 (instant papeda), Group P2 (instant papeda with laor powder (70:30%), and Group P3 (instant papeda with laor powder (60:40%). Instant papeda with laor powder was given starting from day 1 to day 18 of pregancy. On day 19, the surgery was performed and the infants were weighing with digital scale. One Way Anova test 95% CI was used for the statistical analysis. Anova test resulted in significant difference on the changing of body weight during pregnancy. The increase in body weight of rats in the control group was 47.3%, the P1 group was 44.3%, the P2 group was 49% and the P3 group was 60.5%. Instant papeda with laor powder (Eunice viridis) effected (P < 0,05 ) on fetal body weight. Consequesntly, further analysis resulted in the differences between fetal weight of the control group and P3 group. Fetal body weight in P1 group was different from P3 group. Instant papeda with laor powder substituted with 40% laor flour resulted in more fetal body weight than other groups. Keywords: instant papeda with laor powder, weig