Sapporo Medical Journal aims to distribute and expand medical data to the World as well as build a supportive and vibrant community of researchers to connect and explore ideas by publishing articles related to all fields of medicine. Sapporo Medical Journal believes that quality and ethical research. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to:
Abstract : Various devices have employed for percutaneous closure of Patent Ductus Arteriosus (PDA). Although effectiveness of device closure has been determined, a few studies focused on the cost-effectiveness and postoperative complications comparison with open surgery. This study aims to evaluate of PDA occlusion by Amplatzer Ductal Occluder in comparison with open surgical closure. A cross sectional study was performed in children with PDA whom underwent interventions. The interventions including Amplatzer Ductal Occluder and open surgical closure, data of demographic, characteristic PDA, length of stay, costs, interventions, outcome and complication were collected from medical record. Eighteen children (4/18 male) were diagnosed with PDA. The median age was 6.0 years, (SD 9.98). Most of patient suffered from moderate PDA (13/18) and large PDA (5/18). Interventions including Amplatzer ductal occluder (9/18) and open surgical closure (9/18) was found. The surgical group have experienced to care in ICU during hospitalized (9/18, median 0.5-day, p<0.01). The length of stay during hospitalized was longer in surgical group (median 5.5-days, p<0.01). The calculated costs were higher in surgical group (median 28.099.500 IDR, p=0.04). No event of mortality was observed in both of group. Amplatzer Ductal Occluder was more preferable because of its lower inexpensive and complication than surgical technique.
Abstract : ABSTRACT Background: The main causes of maternal mortality are thought to include hemorrhage, sepsis, obstructed labor, and hypertensive desease of pregnancy. For many years, demographic and health surveys have been used to study maternal and perinatal health in developing countries. However few nationwide population surveys have used formally validated questionnaires.Objectives: the purpose of this study was to determine tha validity of maternal self reported of obstetrical complication Methods: a coss-sectional study was conducted among 300 women at Two Hospitals and one public health center, a questionnaire recorded mother’s perception of obstetrical complications while hospital medical record. Sensitifity, spesifisity, predictives values and percent agreement were obtained for obstetrical condition. Result: In general, women’s report of obstetrical complications did not match medical diagnosed. The highest agreement was obstained for reporting eclampsia, with less agreement for post partum haemorrhage Conclusion: The validity of the surveys questionnaires varies between studies due to differences in the questionnaire. Health surveys based on maternal self report must be interpreted with consideration of this limitation. Keywords: Women self-reported; Near Miss; Obstetric Complication; Demographic Health Survey; Epidemiology.
Abstract : Juvenile Systemic lupus erythematosus (jSLE) is a chronic autoimmune disease characterized by overproduction of autoantibody and multiple organ involvement. A cross sectional retrospective study was done in the Allergy Immunology units at Dr Soetomo Academic Hospital, Surabaya. Sixty-three children were evaluated for this study using Mex-SLEDAI. Only children who fulfilled four of eleven 1997 ACR diagnostic criteria were included in the present study. Clinical variables from children were obtained using medical history records and physical examinations; disease activity for each patient was determined using Mex-SLEDAI. Haematological, biochemical parameters, chest radiograph and electrocardiogram (ECG), antinuclear antibodies (ANA) by immunofluorescence method, anti-dsDNA by enzyme linked immunosorbent assay (ELISA), and complement levels were recorded. Anaemia was the most frequent disorder in active jSLE (46.03%) children compared with inactive jSLE children (20.63%), followed by bicytopenia (25.39%) and leukopenia (20.63%). The mean haemoglobin value on admission was 9.41 ± 2.77 g/dL, platelet value was 230.725 ± 156.592, and white blood cell value was 7.353 ± 5.026. Haemoglobin level of all jSLE subjects was 9.73 + 3.835 g/dL. Haemoglobin of active jSLE subjects was lower (between 3.3 to 13.20 g/dL) than the inactive jSLE group (between 3.00 to 14.50 g/dL) (p<0.05). The incidence of bicytopaenia was 4.870 times the active SLE risk (p=0.023). Hb level had negative correla
Abstract : Ventricular septal defects (VSDs) are a common congenital heart disease (approximately 20%). The most common are the perimembranous VSD (around 70%), while completely muscular VSD may occur around 15% of the cases. Supracrystal defects are quite rare accounting for 5% of all VSD. Indications to VSD closure are symptoms of heart failure, signs of left heart chambers overload, and history of endocarditis. The traditional treatment is surgical repair. The surgical approach is considered to be the gold standard, but it is associated with morbidity and mortality, patient discomfort, sternotomy and skin scar. Percutaneous techniques have been developed in order to reduce the impact of such drawback of surgery. Since the first VSD closed by a transcatheter approach by Lock et al. various techniques have been used. Closure of VSD using Ampatzer occluders has been greatly improved and widely reported. VSD inselected patients may be closed percutaneously using an Amplatzer Ductal Occluder II (ADO II) device, as an off-label therapy. It appears that ADO II may be the preferable device for the closure of defects of moderate size (2-5 mm), especially in infants and small children, because of its better profile.
Abstract : Background: Biliary Atresia (BA) is still a challenge because its pathogenesis remains unclear. It is suggested that interferon gamma (IFN-𝛾) has important role in its pathogenesis. Aims: To analyze correlation between IFN-𝛾 expression, cholestasis grading, and biliary atresia incidence in neonatal cholestasis. Methods: It is an analytic observational study within neonatal cholestasis subjects 1-12 months age. Liver biopsies were performed on these subjects. Subjects were divided into biliary atresia and non-biliary atresia according to its histopathology. Then, cholestasis severity were analyzed in its liver specimens and divided into mild, moderate and poor groups. Immunohistochemistry were performed to all of the specimens. Spearman Rank test, Eta Contingency, and Coefficient contingency were performed as statistical tests. Results: There were 34 subjects consists of 20 biliary atresia and 14 non biliary atresia. The average IFN-𝛾 expression in BA group was 11 ± 3.145 cells whereas in non-BA group was 5.928±1.439 cells. Cholestasis severity in BA group were mild (0%), moderate (5%) and 95% had poor grade whereas in non BA group were 21.43%, 50%, and 28.57% respectively. There was significant correlation between IFN-𝛾 expression and BA incidence (r=0,904; p=0,00). There was significant correlation between IFN-𝛾 expression and cholestasis severity grades (r=0,639; p=0,000). There was significant correlation between cholestasis severity grades and BA incidence (r=0,574;