Sapporo Medical Journal

Abstract : Background: Reactive oxygen species (ROS) show a key role in the expansion of tumors. The enzymatic and non-enzymatic antioxidant guarding systems of the cell avoid oxidant harm to various biomolecules by neutralizing produce of free radicals. Glutathione (GSH) and glutathione dependent enzymes [glutathione reductase (GR) glutathione-s-transferase (GST) and glutathione peroxidase (GPx) are the crucial bases of cellular response to oxidative stress. Glutathione acts an essential part in detoxification of carcinogens. Objectives: To assess the role of antioxidant defense an accomplished by glutathione dependent enzymes with their cofactors and comparative investigation activities of the glutathione-dependent enzymes in the blood serum and saliva in the patients with breast cancer. Materials and Methods: Serum and salivary GSH and glutathione dependent enzymes such as GPx, GST, and GR levels were assessed in 40 healthy controls and 48 females with breast cancer utilizing a spectrophotometer. Serum and salivary trace elements (zinc and selenium) were estimated by utilizing the atom absorption photometry. Results: Serum and saliva analysis displayed significantly diminished (P<0.0001) of GSH, GST, GR and GPx activities in breast cancer patients compared to control group. The mean levels of serum and salivary trace elements (zinc and selenium) were significantly reduced (<0.001) in breast cancer patients as compared to levels of healthy controls. Conclusion: Serum and salivary an

Abstract : Background: Preeclampsia is still the main cause of maternal death in Indonesia. Pregnancy care, commonly called Antenatal Care (ANC) is a strategic effort to detect preeclampsia symptoms early, for that ANC must be carried out according to standards. Antenatal care standard consisted of measurements: weight, height, blood pressure, arm circumference, symphysis-fundal height, fetal presentation and fetal heart rate, tetanus toxoid immunization, blood supplement tablets, laboratory tests, case management and interview sessions (counseling), shortened to 10T. Objective: This study measured proportion of antenatal care were in accordance with the standards, how many were diagnosed with preeclampsia and whether standard of antenatal care associated with preeclampsia. Methods: This study used data from Analysis of Indonesian Demographic And Health Surveys (IDHS) 2017. The subjects in this study were women who gave birth last live birth in the 5 years prior to the survey, with 15.021 respondents. Data analysis used multiple logistic regression. Results: 21.5% of pregnant women who received antenatal care according to the standards and 3% who detected preeclampsia. Implement antenatal care standards could detect preeclampsia better than antenatal care unstandardized with an OR of 1.8 (CI= 1.5-2.2).

Abstract : Abstract - In order to preserve sound maternal health, nutrition plays a significant and definite role in the course of pregnancy. This study was aimed to analyze the effect of giving instant papeda with laor powder (Eunice viridis) on the increase in weight pregnant rats and birth weight. An experimental study with Randomized Controlled Trial Post Test Design was performed towards 24 pregnant rat categorized into 4 groups as follows: Control Group (K), Group P1 (instant papeda), Group P2 (instant papeda with laor powder (70:30%), and Group P3 (instant papeda with laor powder (60:40%). Instant papeda with laor powder was given starting from day 1 to day 18 of pregancy. On day 19, the surgery was performed and the infants were weighing with digital scale. One Way Anova test 95% CI was used for the statistical analysis. Anova test resulted in significant difference on the changing of body weight during pregnancy. The increase in body weight of rats in the control group was 47.3%, the P1 group was 44.3%, the P2 group was 49% and the P3 group was 60.5%. Instant papeda with laor powder (Eunice viridis) effected (P < 0,05 ) on fetal body weight. Consequesntly, further analysis resulted in the differences between fetal weight of the control group and P3 group. Fetal body weight in P1 group was different from P3 group. Instant papeda with laor powder substituted with 40% laor flour resulted in more fetal body weight than other groups. Keywords: instant papeda with laor powder, weig

Abstract : As an important factor in achieving a safe life, health has always been the main topic in various conditions. However, one of the obstacles that can threaten these health goals is financial. This literature review discusses how to finance for universal health coverage. This study uses various references, such as journals, reports, news, and scientific articles. This paper describes a systematic analysis starting from the theoretical framework, cost, urgency, and importance of financing for universal health coverage, and discussion. The results show that there is a need for effective financial allocations and regulations to achieve the goal of financing for universal health coverage. In order to obtain references in establishing these financial regulations, Chile and China can be examples of consistently achieving health coverage. Success in achieving universal health coverage will achieve the goal of health security for the entire global community.

Abstract : Bronchial asthma (BA) is an example of a chronic inflammatory process that develops in children in the presence of genetically determined atopy and bronchial hypersensitivity and leads to profound disability in patients 10-24 years [1]. The prevalence of asthma among adults in the world ranges from 1-18%, and among children - 5-10%. In Ukraine, this percentage is only 0.6% -0.56%, which may indicate insufficient diagnosis of this pathology [2]. If children have several diseases that have both acute and chronic course, use the terms "combined pathology", "combined pathology", "concomitant" or "associated" diseases and conditions [3] It should be noted that the term "comorbidity" (comorbidity), used to determine the simultaneous damage of two organs or systems of the body, or the presence of two or the presence of ≥3 comorbidities [4,13], which can be attributed to asthma, because in the vast majority of asthma in children is a primary allergic disease, which causes the development of this pathology with a characteristic comorbid condition, increased blood levels, the main of which are immunoglobulins, erythrocytes, hemoglobin, leukocytes, including eosinophils. and their dependent hematocrit, SaO2. [5].