Sapporo Medical Journal aims to distribute and expand medical data to the World as well as build a supportive and vibrant community of researchers to connect and explore ideas by publishing articles related to all fields of medicine. Sapporo Medical Journal believes that quality and ethical research. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to:
Abstract : Hypertension prevalence increased globally, especially in middle-income and lower-income countries. Smoking was one of the risk factors for triggering the non-communicable disease. Smoking behavior prevalence in Indonesia increased from 12,3% in 2013 to 24,35% in 2018. This study conducted to determine the relationship between smoking behavior and the incidence of hypertension in the medical ward at RSAU M. Salamun Bandung. The research method used was a case-control analytic survey method, which was retrospective in nature. Sampling was purposive sampling, with a total of 28 respondents. Data analysis used the chi-square test showed that there was significance between smoking behavior (p = 0.005, OR = 6,923) and the incidence of hypertension. The hospital needed to increase health education about the negative effect of smoking by campaigning and distributing leaflets or other mass health promotion media.
Abstract : The current study aimed to report the pregnant women knowledge and perception about the feto-maternal care during the pandemic's lockdown. A cross sectional anonymous questionnaire-based study took place in Saudi Arabia. Questions were electronically distributed to participants. The questionnaire includes varieties of questions to gauge their knowledge and perceptions of many pregnancy-related topics in general. It also reported their information and attitude to COVID-19 infection regarding its feto-maternal and neonatal effect and the preventive measures. Three thousand one hundred and seventy-six pregnant females participated in the study. Poor knowledge was reported in (87.9%) of respondents. Meanwhile, 384 (12.1%) had good knowledge. More than half of the women expressed a poor maternal care during the pandemic, although 1415 (44.6%) had a good one. In Conclusion, Saudi Pregnant women living in areas with a higher COVID-19 prevalence, notably, Western, Central and Eastern provinces, expressed more information about the disease. Pregnant females who previously experienced maternal complications and/ or obstructed labor were more knowledgeable about the importance of maternal care. They were eager to undergo feto maternal care, even during the pandemic lockdown. Accurate information about the relationship between COVID-19 vertical transmission and maternal complications must be widely provided to Saudi pregnant ladies.
Abstract : Preeclampsia is the leading cause of morbidity and mortality worldwide. Etiology, and pathophysiology are poorly understood with a recent theory as two stages disorder. The main hypothesis result from a defect in remodelling of spiralis artery, while late-onset preeclampsia is generally considered as maternal factor preeclampsia. Delivery remain the main treatment option, as ACOG already recommended low dose aspirin for high risk pregnancy to reduce mortality rate. Lipid abnormalities has effect on endothelial function which is the main pathogenesis and risk factor of preeclampsia. In pregnancy, lipid metabolism changes occured for fetal growth and development. Pregnant women with preeclampsia has significantly higher lipid profile. Statin is considered safe and has advantages in treating dyslipidemia. Randomized clinical trial were done to assess effect of pravastatin in 71 high risk preeclampsia pregnant women. Clinical trial were done in two groups. Control group (Group A) take 80mg aspirin only as recommended by ACOG until 36 week of pregnancy. Intervention group (Group B) take aspirin and additional 20mg pravastatin twice daily since 18 weeks until 36 week of pregnancy. Maternal lipid profile before and after treatment on both groups were assesed. Maternal outcome and baby outcome were assessed on both groups. There is no significant difference viewed from between groups on initial test of lipid profile. Even after therapy, total cholesterol and triglyceride keep on incr
Abstract : The incidence of premature rupture of membranes is approximately 12% of all pregnancies, although this varies between 2-18% of pregnancies. The pathogenesis and epigenetic aspects of premature rupture of membranes are still unclear. lncRNA, ADAMTS15 mRNA and collagen are associated with premature rupture of membranes (PROM). Thus, this study would like to analyze the correlation of lncRNA BF328678, ADAMTS15 mRNA expression and collagen levels in premature rupture of membranes. The samples taken from two groups of subject, that consist of 20 people with premature rupture of membranes and 20 people without premature rupture of membrans. The mean of lncRNA expression in spontaneous labor with premature rupture of membranes is: 139.1 + 28.94, compared to spontaneous labor without premature rupture of membranes, is: 267.2 + 55.84, with p < 0.05. The mean of ADAMTS15 mRNA expression in spontaneous labor with premature rupture of membranes is: 39.4 + 10.01, compared with the results of expression on spontaneous labor without premature rupture of membranes, is: 6.95 + 2.32, with p < 0.05. The mean of collagen levels in spontaneous labor samples with premature rupture of membranes is: 5.92 + 1.95, compared to spontaneous labor without PROM, is: 6.95 + 2.32, with p < 0.05. It can be concluded that premature rupture of membranes increased expression of ADAMTS 15 mRNA.
Abstract : Background: Hepatic encephalopathy HE is a neuropsychological disorder in patient with advanced liver disease. The ammonia has a critical role in HE pathogenesis. The aim: to evaluate efficacy and safety of sodium benzoate (SB) as a cheap adjunctive agent that can be used in addition to rifaximin or lactulose for the treatment of HE. Methods: This study included 90 patients of overt HE in 3 groups: Group A (30 patients received oral sodium benzoate capsule and lactulose), group B (30 patients received oral sodium benzoate capsules and rifaximin, and group C (30 patients (control group) received lactulose and rifaximin). Each group was subjected to clinical examination, and laboratory investigations. The three groups evaluated before and after treatment for clinical response using West Haven Criteria classification of HE, Clinical Hepatic Encephalopathy Staging Scale (CHESS) score and psychometric tests. Results: There was statistically significant difference in WHC grades of HE, CHESS score of HE, and psychometric tests before and after treatment in each group (P < 0.05). There was no statistically significant difference in the overall improvement between the three studied groups after the treatment regarding WHC grades, CHESS score and psychometric tests. No reported significant adverse events. Conclusion: Adding SB to either lactulose or rifaximin in the treatment of HE is clinically equivalent to lactulose and rifaximin combination. This finding highlights the therapeutic