Sapporo Medical Journal

Abstract : Von Willebrand Factor (vWF) is a multimeric glycoprotein that functions as bridge between platelets and subendothelial tissue, also acts as a carrier of factor VIII. Meanwhile, vWD, a hereditary deficiency of vWF is the most frequent congenital human bleeding disorder that can be classified as type I, II, and III. It has been known that vWF concentration is affected by ABO blood group. The aim of this study is to determine reference value of vWF activities in Indonesian peoples. A cross-sectional study was conducted with 60 subjects of each O blood group and non-O blood group. The activities of vWF were determined by immune-turbidimetric method using Innovance VWF Ac Reagent and Sysmex CS-2100i coagulometer. The measurement principle was an increased turbidity due to agglutination after the addition of polystyrene particle coated with anti GP1b and recombinant GP1b (two gain-of-function mutations included) that bound to the antibody as well as to the vWF of the sample. The reference value of vWF activities in O blood group was 24.2% - 125.4% while in non-O blood group was 37.7% - 166.1%. There was a significant difference between vWF activities in the two groups (p < 0.005). Taken together, our study concluded that the vWF activities of blood group was significantly lower than non-O blood group.

Abstract : BACKGROUND: COVID-19 viral infection has become a global threat since the beginning of 2020. World Health Organization (WHO) has imposed universal recommendations for curfew to control the pandemic. This study designed to evaluate the perception of families within the Gulf Cooperation Countries (GCC) as regards the effect of the curfew on their children. METHODOLOGY: A qualitative cross-sectional questionnaire-based study was performed. This questionnaire was designed in Arabic and distributed electronically among the GCC population with special emphasis on Saudi Arabia. RESULTS: The study included 2006 respondents with a female to male ratio of 5:1. One thousand five hundred twenty-seven of the participants have taught their children the proper etiquette of performing hand hygiene as well as sneezing and/or coughing. Yet, 372 did not consider social distancing as an important issue for their children to learn. Others (118) denoted pediatric unhealthy nutritional habits during the curfew. Overall, 609 of the participants reported the importance of extra supplementary nutrients during the lockdown. Breastfeeding was not a common practice among the participants. CONCLUSIONS: Lack of information among the participants was reported when concerning the crucial effects of dietary and activity habits on children’s immune system during the curfew era. This necessitates the implementation of extra instructional educational social strategies to overcome this defect.

Abstract : There are several ways to consume fruit. Mostly, the forms of fruit which can be consumed are whole fruit and juice. The effect on blood glucose will certainly vary. This study aimed to determine the difference in the increase in blood glucose levels in the Intervention of Soursop fruit and its preparations. The research design used was experimental with pre-post design, the sampling technique used Purposive sampling, and the number of samples was five people and they got three types of Intervention. Whole Soursop fruit group, soursop fruit juice added sugar, and Soursop fruit juice without added sugar. The glucose levels that were measured were fasting blood glucose, glucose levels after consuming three types of intervention at 30 ', 60', 90 'and 120'. The subject is in a healthy sample. The intervention group giving Soursop Juice added sugar and Soursop Juice without sugar, the AUC value was 29.9% and 6% higher than the whole soursop fruit group. The statistical test with the Kruskal-Wallis test was no difference (p = 0.059). It is necessary to be careful in giving diets to diabetes patients because this study uses healthy sample.

Abstract : Tofu and Tempe, as a soybean product, is a popular traditional food originally from Indonesia. Tofu and Tempe are not only a source of protein but also as functional food. Tofu and Tempe are usually consumed as processed by frying or boiling. The cooking process decreases the content of Phytoestrogen. Some compounds of Phytoestrogen are daidzein and genistein. Phytoestrogen is a vegetable hormone, usually in soybean. The function of Phytoestrogen is similar to estradiol in the body. The chemical compound of daidzein and genistein are similar to estrogen in the human body. Aim: To assess the retention of daidzein and genistein due to the cooking process. Methods: Tofu and Tempe got from Jakarta, Depok, and Sumedang area. Time to fry the food is 5 minutes, and to boil is 10 minutes. Analysis of daidzein and genistein is by HPLC. Results: The content of phytoestrogens (daidzein and genistein) in fried tofu decreased by 60.5% and boiled by 63.4%, in fried Tempe decreased by 41.6% and boiled by 17.1%. Conclusions: The retention of phytoestrogens (daidzein and genistein) on fried tofu was 24.2 mg (39.5%), and boiled tofu was 22.4 mg (39.6%), while the retention of Phytoestrogen on fried Tempe was 54.8 mg (58.4%), and boiled Tempe was 77.8 mg (82.9%).

Abstract : Abstract— Cervical Cancer is one of the causes of cancer death. Cervical cancer ranks fourth of the types of cancer in women. Factors associated with the high incidence and death rates in cervical cancer is the low awareness of prevention and early detection. Many factors that influence a person's behavior to act and perform early detection of cervical cancer are related to behavior theory like perceived barriers and cues to action. The aim of this study was to know relation between perceived barriers and cues to action with the intention on cervical cancer early detection based on age, parity, education and knowledge. Design research was cross-sectional with 190 mothers in Bandung City, Indonesia. Data analysis was using Chi-Square test, Breslow-Day, Cochrans’s Mantel-Haenszel,. The results showed that there was a relationship between perceived barrier with intention on cervical cancer early detection based on age, parity, education (P <0.05). There was a relationship between cues to action with intention on cervical cancer early detection based on age, parity, education and knowledge (<0.05). Health workers are expected to give attention determinant factors related as perceived barriers and cues to action in promotion cervical cancer programs.