Sapporo Medical Journal

Abstract : Background: Controversy exist as regards the optimum treatment of pituitary adenoma as it is claimed to be spontaneously regressed. The aim of the current case report with literature review is to highlight the reality of the notion that pituitary adenomas might need no treatment nor surgical intervention due to their spontaneous regression. Methods: We presented here with a case of a 47-year-old female who undergone a strict observation and follow up for pituitary adenoma during a period of 10 years. Review of the literature took place as regards this notion. Conclusion: Pituitary adenomas may need no intervention because they may regress spontaneously. Although the data of one patient is limited it may shed the light on the problem. Further cohort series of this rare condition might be needed to properly investigate the condition.

Abstract : Spectrophotometric techniques can be used to accurately and rapidly determine the concentration of Nitazoxanide in body fluids (serum and urine) through react with diazonium salt ,which result from hydrolyze amino group of 2-Aminobenzothiazole by hydrochloric acid , to formation a precipitate a yellow-orange azo dye. Showed obeyed beers law between 50- 450 μg.mL-1, Molar absorptivity of 0.4916 x103 L mol-1/cm-1 was measured at 478 nm, . for Sandal's sensitivity 0.0132 has a limit of detection (LOD) of 2.96 μg.mL-1 and a limit of quantification (LOQ) of 9.875 μg.mL-1 . This technique has been successfully used to quantify various concentrations of Nitazoxanide in body fluids .

Abstract : In this study, new glycolipids derivatives have been synthesized by modification of the head group. The glycosylation reaction was perform using monosaccharide pentacetates with n-dodecanol in presence of borontriflouride. After deacetylation under basic medium, the benzylidene protecting on 4 and 6 hydroxyls on sugar follow by introducing of two propargylic group on remaining hydroxyls on 2 and 3 positions. The click reaction of sodium azide provide two triazole rings on the final structures of glycolipids 6 and 7. The liquid crystalline phases of the materials were investigated extensively by optical polarized macroscope (POM), and differential scan calorimetry (DSC). The thermotropic behavior of these glycolipids reveal the formation of lamellar phase at the range of 60-70 oC. While the lyotropic under penetration of water reveal a cubic phase for 6 and bi-continues cubic phase for 7. All the compounds was characterized by nuclear magnetic resonance spectroscopy (1H and 13CNMR), Fourier transform infrared spectroscopy (FTIR) and mass spectrometry (MS).

Abstract : The appearance isolates of methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant S. aureus (VRSA), as well as vancomycin-intermediate S. aureus (VISA), in the community, becomes a big concern in worldwide public health in both developed as well as developing countries. Hence, the purpose of the current research aimed to examine phenotypic and genotypic detection of virulence factors in MRSA and VRSA and the frequency of VRSA and VISA isolates among conjunctivitis infections. The results showed that 6 (9.37%) of isolates were capsulated S. aureus by India ink staining, hence 67% of isolates showed the protease enzyme production. The results revealed that 57.8% of S. aureus isolates changed the color of DNase agar from blue to pink or rose, indicating that they were positive result. The results showed that 76.5% of S. aureus isolates produced gelatinase enzyme. The molecular results showed that all of S. aureus isolates do not contain the cap5 gene, while cap8 gene detected in 35% of S. aureus isolates. Also, result pointed out that 50% S. aureus of investigate isolates contained the hla gene. The findings of the molecular revelation of the nuc gene showed that 70% of S. aureus isolate gave positive for nuc gene.

Abstract : COVID-19 pandemic has brought challenges to healthcare service providers, including the pharmaceutical-logistics sector. This study aims to determine the evaluation of the impact of covid-19 on the resilience of inventory management at the Metropolitan Medical Center Hospital. This study uses a qualitative method of a case study with descriptive analysis of several secondary data in the form of reports or documents related to inventory data, patient visit data, as well as hospital income and expenditure data during the Covid-19 pandemic from 2020 to 2021. The research population is management who are involved in the inventory management process at the hospital. This study shows that hospital inventory conditions are not ideal in terms of inventory fulfillment to inventory turnover due to the influence of the pandemic situation which began in 2020 and will continue until 2021. The number of inventory fulfillment for unit requests to warehouses has decreased, especially at the beginning of the pandemic, the inventory turnover rate also decreased, indicating that there were supplies that were not being used because the majority of the supplies needed were centered on the Covid-19 disease with a fairly high number of visits during pandemic. Hospitals need to make various efforts, such as improving forecasting and planning mechanisms, arranging scheduled purchasing, determining drug priorities, and formulating policies according to certain conditions experienced by hospitals.