Sapporo Medical Journal

Abstract : Introduction: Rheumatoid arthritis is a common and systemic disease for unknown reasons. Pulmonary involvement is common in patients with rheumatoid arthritis. Lung ultrasound is a safe, easy, and accessible way to diagnose lung cancer. Therefore, the aim of this study was to investigate the diagnostic accuracy of pulmonary ultrasound (US) to find pulmonary parenchymal involvement in patients in patients with rheumatoid arthritis. Materials and Method: This study was performed cross-sectionally with a descriptive-analytical approach on 123 patients with rheumatoid arthritis. After obtaining written consent, all individuals were undergoing lung ultrasound. The results of ultrasound to determine the diagnostic accuracy of this modality in ILD diagnosis, were compared with the findings of HRCT. In the next step, a checklist also included personal information such as gender, age, smoking and drug history for each patient. The collected data were analyzed after coding and logging into SPSS-21 statistical software and analyzed using appropriate statistical tests. Results: Evidence of ILD in HRCT study was observed in 37 subjects (about 30%). Sensitivity and specificity in ILD diagnosis were 64.8% and 60.47%, respectively. The positive predictive value (PPV), negative predictive value (NPV), positive odds ratio and negative odds ratio were estimated at 41.38%, 80%, 1.64, 0.58, respectively and diagnostic accuracy was 61.79%. Ultrasound sensitivity in both mild and moderate B-Line w

Abstract : Background: Adult Treatment Panel III (ATP III) Metabolic Syndrome Incidence of the National Cholesterol Education Program at 40 years and above 24 % and WHO 21 %. The prevalence of metabolic syndrome in the US was 25 %, 31 % in Padang City, Jakarta, and 21.6 %. Fermented black glutinous rice has a phenolic, flavonoid, anthocyanin, and fiber component believed to prevent regulated metabolic syndrome. Objective: This study aimed to determine the relationship between fermented black glutinous rice consumption and the prevention of metabolic syndrome at age 40 and above in West Bandung Regency, West Java Province. Design: The research used a case-control design. Samples in this study were respondents aged 40 years and over in West Bandung, West Java province, with 57 cases and 57 controls. Data were collected through interviews and physical examinations. Results: The cut-off point at least daily intake of fermented black glutinous rice can prevent the occurrence of metabolic syndrome by more than 11,5 grams per day. The percentage of metabolic syndrome is greater than the proportion of respondents who eat black fermented glutinous rice ≤11.5 grams a day (82.1 a cent). The proportion of non-metabolic syndrome was higher among respondents who used fermented black gluten. Conclusion: It can be inferred that people who eat more than 11,5 grams a day of fermented black glutinous rice have a preventive effect on the occurrence of metabolic syndrome nine times with control variables of

Abstract : Congenital heart disease causes pulmonary arterial hypertension, heart failure, and early death. Pulmonary arterial hypertension causes pulmonary arterial wall remodeling, inflammation, deposition of extracellular matrix protein, collagen synthesis, and fibrosis. This study aims to analyze the effect of Pomegranate extract on pulmonary arterial pressure in Sprague Dawley rats with pulmonary arterial hypertension. Twenty-four Sprague Dawley rat age 3-month bodyweight 250-350 gram allocated randomly into Pomegranate extract and control group, 6 rats in each group. Pulmonary arterial hypertension.was induced with monocrotaline 60 mg/kg body weight injected subcutaneously. Pulmonary arterial pressure both groups were measured at 2 weeks and 4 weeks of observation. Rats were euthanized after 2 and 4 weeks of observation. Mean pulmonary arterial pressure the Pomegranate extract group was significantly lower compared to the control group in two weeks and four weeks of observation, 27,57±9,17 mmHg vs 47,48±5,58 mmHg (p=0.001) and 32,43±9,64 mmHg vs 46,53±5,53 mmHg (p=0.001) respectively. Pomegranate extract can decrease pulmonary arterial pressure in Sprague Dawley rats with pulmonary arterial hypertension induced by monocrotaline. Pomegranate extracts effective preventing the progressivity of pulmonary arterial hypertension in the rat.

Abstract : Hypercholesterolimia becomes one of the factors of vascular disease. The abnormal total cholesterol levels result in inhibition of blood vessels because it can cause atherosclerosis. Anthocyanin that contains in Fermented Glutinous Black Rice as one functional food is recommended to lower total cholesterol levels. The purpose of this study is to determine the effect of fermented Fermented Glutinous Black Rice to total cholesterol levels. This study method used two group pre test and post test experimental design. This research was conducted in January 2017 - February 2017. Samples are residents of Budiharja Village, Cililin sub-district, West Bandung regency, men and women aged over 36 years old with menopause women excluded. The sample of the study amounted to 36 people. The sample was divided into two study groups of each of 18 samples. Before and after the intervention, total cholesterol levels were examined in both groups. Also performed SQFFQ and recall 1x24 hours every three days during the study. The results of the analysis with Dependent T-test of the intervention group showed a decrease in initial total cholesterol levels of 224.61 mg/dL became 194,11 mg/dL with p<0,001. The analysis result with Mann Whitney Test showed that there is decrease total cholesterol level between intervention group and control group (p <0,001). So, one of the way to decreasing the total cholesterol levels could be started by consuming Fermented Glutinous Black Rice.

Abstract : There are still limited data about postoperative delirium (POD) in Indonesia. The purpose of this study was to determine the prevalence of delirium in patients undergoing major orthopedic surgeries and understand its related predictors. This was a retrospective cross-sectional study done in an orthopedic hospital with medical record from January 2016 to December 2019. The subjects were over 60 years old who underwent major orthopedic surgeries (arthroplasty, internal fixation, and spine surgery). POD was diagnosed using Diagnostic and Statistical Manual of Mental Disorders (DSM-V). Univariate and Multivariate logistic regression analysis was used to analyze the possible predictors for delirium. Among 201 patients, there were 20 cases (10%) of POD. Multivariate logistic regression analysis indicated that patients with postoperative anemia [OR: 5.189 (1.086– 24.803)], given general anesthesia [OR: 9.194 (1.713 – 49.333)], limited mobility [OR: 17.575 (1.646 – 187.627)], and suffers from sleep disturbance [OR: 35.925 (8.143 – 158.497)] were more likely to develop delirium. POD’s predictor seen in geriatric patients undergoing major orthopedic surgery were mobility restriction, sleep deprivation, postoperative anemia, and general anesthesia. These predictors will help to identify patients with high risk of delirium and could be a potential target for intervention.