Sapporo Medical Journal aims to distribute and expand medical data to the World as well as build a supportive and vibrant community of researchers to connect and explore ideas by publishing articles related to all fields of medicine. Sapporo Medical Journal believes that quality and ethical research. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to:
Abstract : In rheumatoid arthritis patients the risk of cardiovascular affection is 2–3 times higher than the general population, with increased morbidity and mortality. This is due to increase in the traditional and nontraditional risk factors. The aim of this study is to determine the cardiovascular risk in patients with RA using four established CV risk algorithms Framingham Risk Score (FRS), Systematic Coronary Risk Evaluation Score (SCORE], Reynolds Risk Score (RRS), Q II Risk Score and there relation with serum levels of leptin and interleukin-6 (IL-6). Methods:Cross sectional study was conducted during the period between December 2018 and June 2019 Sixty seven RA patients were enrolled in this study. The 10-year CVR for RA patients were calculated using FRS, SCORE, RRS and Q II Risk Score. Serum leptin and IL-6 were estimated. Results:The results showed a significant difference between higher leptin values and disease activity, obesity, positive RF and longer disease duration, On the other hand, we found a significant difference between higher IL-6 values and disease activity, and hypertriglyceridemia. As regarding correlations of IL-6 and Leptin with different cardiovascular scores, there were no significant correlations with exception of moderate significant correlation between IL-6 and RRS (r= 0.42, P< 0.001). Conclusion:We found no correlation between CVR scores and leptin or IL-6 except for RRS and IL-6, therefore new models of CVD risk prediction incorporating RA specific
Abstract : Studies on the degree of adherence to folic corrosive (FA) and elements related were limited in a wide assortment and affirmed inconsistency in the indistinguishable area and among uncommon populaces. by means of recognizing those components, there could be a chance to improve the consistence and afterward decline in the commonness of undesirable outcomes as NTD. The medicinal services organizations have a critical job in this adherence. A go-sectional see that utilizes a multistage examining approach transformed into utilized. It becomes directed among various number one medicinal services habitats in Al-Ahsa town. The example size transformed into 176 pregnant women dependent on the prevalence of acknowledgment concerning FA consumption during being pregnant. It transformed into 160 above all else, be that as it may, 10% of victims were presented so one can control the dropouts. the predominance of utilization of FA among pregnant in their first trimester transformed into agreeable (87%). least complex 2% of pregnant have a past little child with NTD. by methods for surveying the FA adherence degree, we found that lone 15% are particularly disciple. A not strange thought process (71%) of low adherence changed into distraction auxiliary to dealing with others watched by means of being a working mother and ignorance of FA essentialness. 13% of pregnant did now not take FA in any regard. the principle intentions in the rear of the non-utilization of FA as member referred to th
Abstract : Rising diseases have caused a giant impact on humankind as a result of their unexpected occasions at a sporadic time and spot. Advancement of viral illnesses happens when etiological diseases cross their run of the mill nooks or edges. These contaminations have mixed open care as a result of the advancement on various stages, especially media. The clarification behind creation such perilous care is the approaching high distressingness and mortality brought about by these diseases. Though most of them are non-immune response preventable, early clinical finding and palliative thought with extraordinary ailment control practices can check scenes and pandemics.
Abstract : This assessment was grasped to investigate the apportionment of etiological masters and antimicrobial resistance plan among the blood culture-positive cases of neonatal sepsis admitted to a measurement III neonatal thought unit in a demonstrating clinical facility Kolkata, Eastern India for the hour of 4 years (2014 – 2017). Blood culture was cultivated for all newborn children surrendered with clinical sepsis or with positive sepsis screen by means of automated BACTEC 9050 structure. In positive cases, recognizing confirmation of animal was done trailed by antimicrobial affectability testing by Kirby Bauer plate dispersal technique using Clinical Research Center Standard Organization Rules. Multi-quiet impediment (MDR) was described as the closeness of assurance from at any rate three of the five enemy of microbial social occasions if there ought to emerge an event of gram-negative infinitesimal living beings. Chi-squared test was performed to test the connection between different social events. Out of 4781 examples of clinical neonatal sepsis, 415 (8.68%) were culture positive. In 240 (69%) cases, the pathogens had a spot with the family Enterobacteriaceae. Gram-positive cocci speak to 38 (11%) occasions of positive blood culture cases. Klebsiella is the superior powerful administrator with positive in 187(54%) of every single bacterial isolate. Enterobacteriaceae positive youngsters had 90 (36.9%) passing which is in a general sense higher than that related with others. Kl
Abstract : Dysfunctional uterine bleeding is a major gynecologic hassle, with numerous remedy options. A good sized percentage of these sufferers go through hysterectomy. to analyze the hormonal milieu at the tissue degree, we semi-quantitatively assessed the estrogen and progesterone receptors in the endometrial samples of fifty DUB sufferers, by way of Immunohistochemistry. We observed a big boom (p < 0.001) within the concentration of both estrogen and progesterone receptors in patients with dysfunctional uterine bleeding, in comparison to the regular populace. We also mentioned a substantial growth inside the endometrial thickness (p < 0.001) of sufferers with easy endometrial hyperplasia. Our look at demonstrates the position of estrogen and progesterone receptors in the etiopathogenesis of dysfunctional uterine bleeding and within the alteration within the morphology of endometrium, consisting of easy endometrial hyperplasia. We suggest the usage of progesterone antagonists and selective progesterone receptor modulators within the remedy of patients with dysfunctional uterine bleeding, especially in people with endometrial hyperplasia, who convey the longtime danger of endometrial carcinoma with sustained endometrial estrogenic stimulation.