Sapporo Medical Journal

Abstract : Abstract Colon cancer is one of the most common cancers around the world. It is classified as the third cancer that affects humans. Many studies show risk factors for cancer. This study was designed as a reference study (retrospective). This study was conducted in Dhi-Qar Governorate at Al-Hussein Hospital, peace be upon him, and included the collection of colon and rectal tissue samples immersed in paraffin wax for patients with colon cancer, during the period from October 2020 to April 2021 at the age of 20 years The aim of the study is to diagnose the presence of the cryptosporidium parasite in the tissues of colorectal cancer patients by using polymerase chain reaction (PCR). The results of the polymerase chain reaction showed infection in Cryptosporidium parasite 13.3% (13) positive samples out of 75 samples, and infection in Cryptosporidium parfum 9.2% (9) positive samples. The study also recorded a discrepancy between infection rate and gender. The infection rate of Cryptosporidium (8) samples 66.7% and Cryptosporidium parvum (5). The study also showed the most prevalent stages of cancer and the most common stages in which Cryptosporidium are present. The study recorded the second stage of colon cancer patients with the most diagnosed stages, as well as the presence of Cryptosporidium in it (4) 33.3%. But Cryptosporidium recorded the most infection in the first stage of colon cancer (4) 50%.

Abstract : Infected wounds are one of the most common health issues today, and there are numerous treatment options. These treatments, however, have drawbacks and are frequently expensive. We can produce a more effective, less expensive wound dressing for the treatment of infected wounds by employing chitosan or nano-chitosan alone or by combining each material with a pre-existing silver antibacterial like silver sulfadiazine. These findings demonstrate the combination of actives that inhibit and kill certain wound pathogens in a polymeric gel wound dressing after a series of antimicrobial efficacy tests in vitro and in vivo.

Abstract : The purpose of this study was to predict the outcome of critically ill patients by change of TNF serum level comparing it with q SOFA and APACHE II scores. It included 150 critically ill patients were admitted to Assuit University Hospitals ICUs. All patients underwent carful medical history, clinical examination, abdominal us and ECG. Serum samples were collected for TNF and routine investigations included renal and liver function tests, CBC, ABG, and LDH. There was significant correlation between short term mortality and serum levels of TNF, APACHE II and q SOFA scores as (P were 0.005, 0.01, 0.002 respectively). TNF and q SOFA had significant correlation with Long-term mortality (P were 0.006, 0.001 respectively) but APACHE II had insignificant correlation with Long-term mortality as (P was 0.059). TNF and APACHE II had significant correlation with hospital stay length (P were 0.001, 0.001 respectively) while q SOFA had insignificant correlation with hospital stay length as (P was 0.6). This study concludes that TNF is good predictors for mortality (short and long term) and the duration of hospital stay.

Abstract : Background: AML is a heterogeneous haematological malignancy , it is the most common acute leukemia in adults. FLT3 is the most common molecular aberration in AML , belongs to the group of class III receptor tyrosine kinases (RTKs) which also include the receptors c-kit and c-fms and PDGFR, mutated in more than one third of the AML cases, subdivided into two major classes :internal tandem duplication(ITD) and tyrosine kinase domain(TKD).FLT3/ITD is associated with higher probability of relapse and worse outcome, and however, there is controversy about its impact on the induction outcome. Objectives: 1.The prevalence of the FLT3/ITD mutation in Iraqi adult de-novo AML patients 2. The effect of the FLT3/ITD mutation on the remission induction outcome (CR rate) 3. The association of this gene with the laboratory tests(WBC, Hb ,PLT ,BM blast %) Patients and methods: This Cohort study comprised 41 adult de-novo AML patients, admitted in Baghdad medical city complex from Jan.2018 to Dec.2019, Each patient was investigated by complete blood count and differential, bone marrow aspiration and biopsy as well as immunophenotyping to confirm the diagnosis of AML.All of them had received the standard (3+7 ) protocol.FLT3 gene was screened by expert genetist using conventional PCR technology with special primers in teaching laboratories/molecular unit in Baghdad medical city complex, just at time of diagnosis . The post-induction assessment was done by examination of bone marrow

Abstract : Abstract : Human Immunodeficiency Virus (HIV) infection can be caused damage to the immune system and leading to immunocompromised conditions, making the person more likely to get other infections. Myiasis is a maggots infestation in the human body, in immunocompromised conditions, it can lead to severe conditions and cause death. Human cerebral myiasis in HIV patients is a rare condition. HIV Infection and type 2 Diabetes Mellitus (DM) play a major role in immune system dysregulation which leads to immunocompromise. Hereby, we report those case with its management.