Sapporo Medical Journal

Abstract : Objectives: This study evaluates the impact of long-term tramadol use on Erectile Dysfunctions and Other Male Sexual Functions. Methods: This was a cross-sectional study carried out over a period of 6-months among 68 clients with tramadol use (history of tramadol use and positive urine examination). The subjects selected from Hot Line Clinic of Minia Psychiatric Hospital, Upper Egypt. They underwent to complete physical and neurological clinical evaluation and assessment. Then, each patient screened with addiction severity index (ASI) and international index of erectile function (IIEF). The control group consisted of 43 subjects with no history of drug abuse and negative urine analysis test. A written consent from subjects was taken. The study was approved from local committee of Minia University. Results: Sixty eight subjects with tramadol use were recruited for this study. The mean age at onset of tramadol use was 26.24 ± 6.472 years. The mean duration of tramadol use was 7.74 ± 3.610 years. According to ASI, psychiatric state, drug use, and family and social domains were the most severely affected domains among the tramadol users. Also, there was a statistical significant difference between tramadol use group and the control regarding erectile function, sexual desire, orgasm, intercourse satisfaction and overall satisfaction as measured by IIEF (p < 0.000). There was a statistically significant negative correlation between average daily dose of tramad

Abstract : The emergence of resistant Klebsiella pneumoniae assosiated with COVID-19 demonstrate a primary challenge for the antimicrobial therapy of infectious diseases and increases the incidence of mortality and morbidity. K. pneumoniae isolated from COVID-19 patients sputum with ratio (100%). All K. pneumoniae clinical isolates had 100% resistance to ceftriaxone , piperacillin (80%) , cefepime (60%) , amikacin (40%) , and meropenem =levofloxccin (20%). Bacterial isolates gave positive result for MHT, also all isolates formed ‎ β- lactamase at a rate of 100% by using spectrometry β-lactamase assay. Costunolide (38.3 %), Rutin (15.33%), Pentadecanoic acid (6.54%), Oliec acid (4.77%), and Caproic acid (3.22%) considered as major compounds in Saussurea costus were identified by GC-Mass spectrometry . The β-lactamase produced by K. pneumoniae were inhibited by Saussurea costus with a strong statistical significance at P- value : <0.001.

Abstract : BACKGROUND: The exact mineral content of deciduous 2nd molars (DSM) in prenatal, postnatal enamel and neonatal line is not fully determined. AIM: To determine the morphology and mineral content of prenatal, postnatal enamel and neonatal line. MATERIAL AND METHODS: 5 human exfoliated DSM were collected, each tooth was divided into two halves so that 10 samples were obtained. Prenatal, postnatal enamel and neonatal line were examined. Samples were assessed morphologically by light microscope (LM), stereomicroscope and Scanning electron microscope (SEM). Moreover the samples were assessed for mineral analysis and all data were statistically analyzed. RESULTS AND CONCLUSION: In DSM, Morphological study revealed that, postnatal enamel of DSM was more translucent in color than prenatal enamel in stereomicroscope. The neonatal line had chalky white appearance in stereomicroscope. SEM morphometric analysis showed an increase in surface area of postnatal enamel rods whereas, their number showed a decrease when compared to prenatal enamel. Elemental study of showed a significant increase in Calcium (Ca) and Ca/P ratio weight % and non-significant decrease in Phosphorous (P) weight % when prenatal compared to postnatal enamel and when postnatal enamel compared to neonatal line. C weight % of prenatal enamel decreased significantly when compared to postnatal enamel and decreased non-significantly when postnatal enamel was compared to neonatal line. Magnesium (Mg) and sodium (Na) weight

Abstract : Genetic and population-statistical results of association of alleles and genotypes of rs1805010 lle50Val polymorphism of IL4RA gene are analyzed, in 75 patients with atopic bronchial asthma and 25 healthy children, depending on the article, type of inheritance, homozygous or heterozygous genotype. The results of the study showed that in general the increased risk of developing allergic asthma in children is determined in carriers of homozygous genotype A/A polymorphism rs1805010 lle50Val gene IL4RA, because in patients with asthma, it occurs 4.34 times more often than in almost healthy children (OR = 6.10; 95% CI [1.33-27.93]; p <0.003), than in almost healthy children. The association of the lle50Val polymorphism of the IL4RA gene in rs1805010 with the development of bronchial asthma by us among girls has not been established, , while the homozygous genotype G / G is more common (0.368) among boys who have, accordingly, a reduced risk of developing bronchial asthma (OR = 0.34; 95% CI [0.16-0.73]; p = 0.003).

Abstract : Food processing with deep fat frying method with palm oil has been frequently made either by restaurants, caterings, or food industries in Indonesia. It has been identified that the frying process with high temperature and long frying duration cause of the oil damage. The objective of this review is to describe the chemical change in palm oil during the frying process with deep fat frying method and to evaluate the results of oxidation, hydrolysis, and polymerization reactions during the frying process. The frying temperature between 150-250oC, frying duration until 48-50 hours, the repeated oil use caused the decomposition of some triglycerides, the composition change of saturated fatty acids (SFA), mono-unsaturated fatty acids (MUFA), poly-unsaturated fatty acids (PUFA), and the formation of aldehyde compound, short chain fatty acids, ketone compound categorized as volatile and non-volatile compounds. The evaluation of the oil quality during the frying process taking into account the peroxide, iodine, para-anisidine, free fatty acid values and the percentage of total polar compounds is also discussed in this review. The toxic contaminant compounds due to high temperature frying (in average 180oC) have been formed. They are trans-fatty acids i.e. elaidic (C18:1,9t) and trans (C18:2,9C12t/9t12c). Glycidyl esters compound are formed in palm oil during temperature deodorization process of >230oC. The contaminant concentration reduces during the frying which are observed from so