Sapporo Medical Journal

Abstract : Irreducible dorsal dislocation of the interphalangeal joint of the great toe is extremely rare. Here, we report a case of a 27-year-old male patient with an open dorsal dislocation of the left great toe resulting from a twisting injury while playing football. After the affected site was washed with normal saline, manual closed reduction was performed, but it failed because of bony and soft tissue entrapment. Nevertheless, it was successfully managed by open reduction and internal fixation using Kirschner wire. In addition, the interposition of the joint capsule and hallux sesamoid was found and reduced. This case is the first to be reported in the Middle East and the first to be reported as open dislocation worldwide.

Abstract : Heterotopic ossification (HO) is a rare preventable debilitating complication of immobility. We reported 2 cases of traumatic brain injured patients who has been bedridden and subsequently develop HO at bilateral hips for case number one and at unilateral elbow for case number two. Although they had a good cognitive recovery, the HO had hinder their everyday mobility and living activity potential. The interdisciplinary medical discussion with the patients had led to surgical removal of the heterotopic ossifications in both cases. Their quality of life improved tremendously following the intervention. This article illustrates the importance of a multidisciplinary approach and knowledge of various methods in the management of multiple disabilities that can help to achieve a realistic meaningful goal for the patients.

Abstract : This study was conducted to determine the effect of oral extract of O. stamineus in the management of diabetes in normal and alloxan-induced diabetic rats. The rats were divided into four groups, with ten rats. Group A (control) consisted of normal rats that received 2 ml (10 ml/kg of body weight) of normal saline per day. In comparison, group B consisted of diabetic rats that received 1 ml (120 mg/kg of body weight) of treatment with extract of O. stamineus. On the other hand, Group C consisted of diabetic rats given 1 mL (150 mg/kg body weight) of metformin. On the other hand, Group D was made up of untreated diabetic rats who served as a negative control group. Alloxan (150 mg/kg body weight) was injected intraperitoneally into groups B, C, and D. Diabetic group B rats given O. stamineus extract had considerably lower blood glucose levels than diabetic group D rats (p = 0.05). Similarly, diabetic rats in group B consumed significantly less food and water than diabetic rats in group D (p = 0.05). After that, diabetic group B rats given O. stamineus extract had a considerable increase in body weight (p = 0.001). In conclusion, O. stamineus extract can reduce alloxan-induced hyperglycemia in diabetic rats and prevent weight loss in diabetic animals.

Abstract : ABSTRACT The prevalence of both asthma and obesity is increasing, and studies have found a correlation between these conditions. Obesity is also related to poor asthma control (Pradeepan et al., 2013). Objective: The main study objective was to identify the impact of BMI on the frequency of ER visits and length of hospitalization among asthmatic patients aged 14 or less in Makkah from 2018 to 2022. Method: This was a retrospective cross-sectional quantitative study using data collected from the hospital system. Results: This study found no significant correlation between BMI and asthma control (p = 0.935), compared to previous studies. Additionally, the correlation between BMI and frequency of hospitalization and ER visit results was not statistically significant. Finally, this study found an association between male gender and BMI as the p-value found by a Pearson Chi-squared test was less than the level of statistical significance (p < 0.05). Obesity is more prevalent in boys than in girls, and boys are also more likely to suffer from asthma. Conclusion: Asthma is a major public health disease that affects the quality of life, and one of the most important factors affecting the disease is obesity but obesity does not affect the severity of asthma as our study showed

Abstract : Musk is a biological secretion with a unique odor produced by the Moschus moschiferus Linnaeus. Although musk was used as an anti-inflammatory, antibacterial, analgesic, antipyretic, anti-ischemic, and anti-infective in Traditional Mongolian Medicine, it has not been standardized until now. This study aimed to conduct a standardization study with focus on the determination of the quality and safety parameters of musk and evaluate the antipyretic effect of the musk by yeast-induced model of fever. The musk was extracted from the domesticated musk deer from the Musk Deer Breeding Center of the ITMT was used in this study. The content of the muscone in the natural musk was determined by HPLC method. Mice were fevered by injecting 20 mg/kg of Brewer’s yeast subcutaneously. Then, rectal temperature was recorded by thermometer for six (6) hours. In this study, the musk reduced the body temperature significantly after yeast injection compared to the control group (*p<0.01). Suitable conditions of HPLC revealed the presence of muscone in natural musk and the content of muscone in natural musk was determined at 0.31±0.005%. The quality and safety parameters of natural musk were determined: moisture content is at 24.88±0.85%, total ash at 2.62 ± 0.32% while aerobic microbes, yeast, and mold were not detected in the Musk. The standardization indicators of natural musk were defined and the Mongolian National Pharmacopeia Monograph’s draft for natural Musk was developed.