Sapporo Medical Journal

Abstract : Abstract—Health monitoring of radiation workers due to radiation exposure can be done by examination of the hematopoietic system, especially white blood cells which are very sensitive to radiation exposure and can be used as an indicator of body damage. The purpose of this study was to determine the differences in the biological effects of ionizing radiation on the hematopoietic system of radiation workers and non-radiation workers as controls. A total of 3 mL of blood from 57 people (34 radiation workers and 23 subjects as a control) were taken using a syringe and then put into an EDTA tube and shaken slowly to avoid clotting. The blood was examined using the ABX Micros 60 hemoanalyzer instrument with standard procedure in the PTKMR Laboratory. An independent sample T-test was used to determine the significant differences between radiation workers and controls. Pearson chi-square test was used to evaluate the significance of each parameter through p-value (p<0.05). The results showed that the numbers of hemoglobin, erythrocytes, leukocytes, platelets, hematocrits, MCV, MCH, MCHC, RDW, MPV, PDW, lymphocyte, monocytes, granulocytes, % lymphocytes, % monocytes, % granulocytes of radiation workers did not decrease and still within normal limit. The results of the statistical test did not show a significant difference between radiation workers and controls (p> 0.05). It was concluded that radiation workers did not have any impact due to work with radiation.

Abstract : Bacterial activity is one of the factors involved in the pathogenesis of acne vulgaris (AV). Previous studies reported that other bacteria found in addition to P. acnes in AV lesions, may also play a role in acne pathogenesis. Furthermore, an increase in antibiotic resistance towards these bacteria become problems. The aim of this study was to identify bacteria and determine antibiotic resistance from comedones of AV patients in Dr. Hasan Sadikin General Hospital West Java, Indonesia. A descriptive cross-sectional study was undertaken from January to February 2019. A total of 30 samples were collected from closed comedone, then cultured under aerobic and anaerobic conditions. Species identification was done by Vitek® 2 compact. The isolates were tested for resistance to nine antibiotics by disk diffusion methods. The result of this study consisted of 53.6% P. acnes, 17.9% Staphylococcus epidermidis (S. epidermidis), 10.7% Staphylococcus hominis ssp. hominis (S. hominis spp. hominis), 7.1% Staphylococcus capitis (S. capitis), 1,8% for each of Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus warneri, Pseudomonas aeruginosa, Klebsiella pneumoniae spp. pneumoniae, and Enterobacter aerogenes. The two most common bacteria in one comedone were P. acnes concurrently with S. epidermidis. The highest antibiotic resistance of all bacteria was against clindamycin (62.5%), azithromycin (60.7%), erythromycin (57.1%), cotrimoxazole (46.4%), tetracycline (28.6%), levofloxac

Abstract : Relationship between Covid19 & androgen receptor

Abstract : Rheumatoid arthritis (RA) and systemic lupus erythematosus are considered chronic inflammatory autoimmune diseases with unknown etiology and systemic involvement.Both PLR and NLR are associated with the inflammatory status. Based on this, wehypothesized that both NLR and PLR may also be correlated with the disease activity of RA and SLE

Abstract : In rheumatoid arthritis patients the risk of cardiovascular affection is 2–3 times higher than the general population, with increased morbidity and mortality. This is due to increase in the traditional and nontraditional risk factors. The aim of this study is to determine the cardiovascular risk in patients with RA using four established CV risk algorithms Framingham Risk Score (FRS), Systematic Coronary Risk Evaluation Score (SCORE], Reynolds Risk Score (RRS), Q II Risk Score and there relation with serum levels of leptin and interleukin-6 (IL-6). Methods:Cross sectional study was conducted during the period between December 2018 and June 2019 Sixty seven RA patients were enrolled in this study. The 10-year CVR for RA patients were calculated using FRS, SCORE, RRS and Q II Risk Score. Serum leptin and IL-6 were estimated. Results:The results showed a significant difference between higher leptin values and disease activity, obesity, positive RF and longer disease duration, On the other hand, we found a significant difference between higher IL-6 values and disease activity, and hypertriglyceridemia. As regarding correlations of IL-6 and Leptin with different cardiovascular scores, there were no significant correlations with exception of moderate significant correlation between IL-6 and RRS (r= 0.42, P< 0.001). Conclusion:We found no correlation between CVR scores and leptin or IL-6 except for RRS and IL-6, therefore new models of CVD risk prediction incorporating RA specific