About

Sapporo Medical Journal

Sapporo Medical Journal is an open access, monthly, peer reviewed International Medical Journal with focuses on publishes research conducted in all fields of medical, medicine. There is no restriction on the length of research papers and reviews, although authors are encouraged to be concise. Sapporo Medical Journal is a scopus indexed International Medical Journal that wants to publish original articles, research articles, review articles with top-level work from all areas of Medicine, General Medicine, Medical Science Research and their application including Aetiology, bioengineering, biomedicine, cardiology, chiropody etc.
Sapporo Medical Journal
Sapporo Medical Journal
Sapporo Medical Journal
Sapporo Medical Journal
Sapporo Medical Journal
Sapporo Medical Journal
Sapporo Medical Journal
Sapporo Medical Journal
Sapporo Medical Journal
Sapporo Medical Journal
Sapporo Medical Journal

Sapporo Medical Journal aims to distribute and expand medical data to the World as well as build a supportive and vibrant community of researchers to connect and explore ideas by publishing articles related to all fields of medicine. Sapporo Medical Journal believes that quality and ethical research. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to:

Medicine Microbiology Biochemistry Pharmacology Pathology Forensic medicine Internal Medicine Physiology Anatomy Obstetrics and Gynecology Radiology Community Medicine Otorhinolaryngology Infectious Diseases General Surgery Cancer research Pulmonary Dermatology and Venereal diseases Orthopedics Neurology Anaesthesia Medical education Infectious Diseases and Vaccinology Neurosurgery Gastroenterology Nephrology Paediatrics Reproduction Dental Cardiology Surgery Nursing Otolaryngology Dermatology Diabetes Orthopaedics Hepatology Urology Psychology Anesthesiology Endocrinology Biotechnology Venereology ENT Psychiatry Pharmaceutical Analysis Pharmacy Pharmaceutical Chemistry Pulmonology Pharmaceutics Pharmaceutical Pharmacognosy Biopharmaceutics Phatmaceutical Technology Quality Assurance Pharmacodynamics Pharmacokinetics Drug Regulatory Industrial Pharmacy Pharmaceutical Nanotechnology Drug Design Affairs Phytochemistry Drug Delivery Systems Drug Discovery Pharmaceutical Microbiology Pharmacy Practice Hospital Pharmacy Clinical Pharmacy Pharmacogenomics Drug Metabolism Pharmacovigilance Toxicology Clinical Research Microbiology Phrmacoinformatics Life Sciences like Chemistry Epidemiology Biomedical Sciences Immunology Dentistry Oncology Biomedicine Physiotherapy Sexology Neuroscience Gynaecology Dermatoepidemiology Pharmacy and Nursing Angiology/Vascular Medicine Osteology Ophthalmology Haematology Kinesiology Critical care Medicine Pharmacognosy and Phytochemistry Clinical immunology Bariatrics Genomics and Proteomics Clinical and Hospital Pharmacy Radiobiology Cell Biology Geriatric Medicine Healthcare Services Healthcare Management Bioinformatics and Biotechnology
Paper ID : SMJ2409205408132
Sapporo Medical Journal
Author : Ika Fitria Elmeida, Endang L Achadi, Dwiana Ocvianti, Siti Nurul Qomariyah,

Abstract : ABSTRACT Background: The main causes of maternal mortality are thought to include hemorrhage, sepsis, obstructed labor, and hypertensive desease of pregnancy. For many years, demographic and health surveys have been used to study maternal and perinatal health in developing countries. However few nationwide population surveys have used formally validated questionnaires.Objectives: the purpose of this study was to determine tha validity of maternal self reported of obstetrical complication Methods: a coss-sectional study was conducted among 300 women at Two Hospitals and one public health center, a questionnaire recorded mother’s perception of obstetrical complications while hospital medical record. Sensitifity, spesifisity, predictives values and percent agreement were obtained for obstetrical condition. Result: In general, women’s report of obstetrical complications did not match medical diagnosed. The highest agreement was obstained for reporting eclampsia, with less agreement for post partum haemorrhage Conclusion: The validity of the surveys questionnaires varies between studies due to differences in the questionnaire. Health surveys based on maternal self report must be interpreted with consideration of this limitation. Keywords: Women self-reported; Near Miss; Obstetric Complication; Demographic Health Survey; Epidemiology.

Paper ID : SMJ2409205408131
Sapporo Medical Journal
Author : Zahrah Hikmah, Anang Endaryanto, Andi Cahyadi, Syaiful Arifin,

Abstract : Juvenile Systemic lupus erythematosus (jSLE) is a chronic autoimmune disease characterized by overproduction of autoantibody and multiple organ involvement. A cross sectional retrospective study was done in the Allergy Immunology units at Dr Soetomo Academic Hospital, Surabaya. Sixty-three children were evaluated for this study using Mex-SLEDAI. Only children who fulfilled four of eleven 1997 ACR diagnostic criteria were included in the present study. Clinical variables from children were obtained using medical history records and physical examinations; disease activity for each patient was determined using Mex-SLEDAI. Haematological, biochemical parameters, chest radiograph and electrocardiogram (ECG), antinuclear antibodies (ANA) by immunofluorescence method, anti-dsDNA by enzyme linked immunosorbent assay (ELISA), and complement levels were recorded. Anaemia was the most frequent disorder in active jSLE (46.03%) children compared with inactive jSLE children (20.63%), followed by bicytopenia (25.39%) and leukopenia (20.63%). The mean haemoglobin value on admission was 9.41 ± 2.77 g/dL, platelet value was 230.725 ± 156.592, and white blood cell value was 7.353 ± 5.026. Haemoglobin level of all jSLE subjects was 9.73 + 3.835 g/dL. Haemoglobin of active jSLE subjects was lower (between 3.3 to 13.20 g/dL) than the inactive jSLE group (between 3.00 to 14.50 g/dL) (p<0.05). The incidence of bicytopaenia was 4.870 times the active SLE risk (p=0.023). Hb level had negative correla

Paper ID : SMJ2409205408130
Sapporo Medical Journal
Author : I Ketut Alit Utamayasa, Mahrus Abdur Rahman, Taufiq Hidayat, Feranti Meuthia2,

Abstract : Ventricular septal defects (VSDs) are a common congenital heart disease (approximately 20%). The most common are the perimembranous VSD (around 70%), while completely muscular VSD may occur around 15% of the cases. Supracrystal defects are quite rare accounting for 5% of all VSD. Indications to VSD closure are symptoms of heart failure, signs of left heart chambers overload, and history of endocarditis. The traditional treatment is surgical repair. The surgical approach is considered to be the gold standard, but it is associated with morbidity and mortality, patient discomfort, sternotomy and skin scar. Percutaneous techniques have been developed in order to reduce the impact of such drawback of surgery. Since the first VSD closed by a transcatheter approach by Lock et al. various techniques have been used. Closure of VSD using Ampatzer occluders has been greatly improved and widely reported. VSD inselected patients may be closed percutaneously using an Amplatzer Ductal Occluder II (ADO II) device, as an off-label therapy. It appears that ADO II may be the preferable device for the closure of defects of moderate size (2-5 mm), especially in infants and small children, because of its better profile.

Paper ID : SMJ2409205408129
Sapporo Medical Journal
Author : Bagus Setyoboedi, Ahmad Mahfur, Alphania Rahniayu, Anang Endaryanto, Sjamsul Arief,

Abstract : Background: Biliary Atresia (BA) is still a challenge because its pathogenesis remains unclear. It is suggested that interferon gamma (IFN-𝛾) has important role in its pathogenesis. Aims: To analyze correlation between IFN-𝛾 expression, cholestasis grading, and biliary atresia incidence in neonatal cholestasis. Methods: It is an analytic observational study within neonatal cholestasis subjects 1-12 months age. Liver biopsies were performed on these subjects. Subjects were divided into biliary atresia and non-biliary atresia according to its histopathology. Then, cholestasis severity were analyzed in its liver specimens and divided into mild, moderate and poor groups. Immunohistochemistry were performed to all of the specimens. Spearman Rank test, Eta Contingency, and Coefficient contingency were performed as statistical tests. Results: There were 34 subjects consists of 20 biliary atresia and 14 non biliary atresia. The average IFN-𝛾 expression in BA group was 11 ± 3.145 cells whereas in non-BA group was 5.928±1.439 cells. Cholestasis severity in BA group were mild (0%), moderate (5%) and 95% had poor grade whereas in non BA group were 21.43%, 50%, and 28.57% respectively. There was significant correlation between IFN-𝛾 expression and BA incidence (r=0,904; p=0,00). There was significant correlation between IFN-𝛾 expression and cholestasis severity grades (r=0,639; p=0,000). There was significant correlation between cholestasis severity grades and BA incidence (r=0,574;

Paper ID : SMJ2309205408124
Sapporo Medical Journal
Author : Amir-Reza Dalili, Banafsheh Ghavidel-parsa, Saeid Sadeghi Joni, Poupak Tohidi Kaloorazi, Seyyed Mohammad Mousavi, Yasaman Soleimanmanesh, Nazanin Soleimanmanesh,

Abstract : Introduction: Rheumatoid arthritis is a common and systemic disease for unknown reasons. Pulmonary involvement is common in patients with rheumatoid arthritis. Lung ultrasound is a safe, easy, and accessible way to diagnose lung cancer. Therefore, the aim of this study was to investigate the diagnostic accuracy of pulmonary ultrasound (US) to find pulmonary parenchymal involvement in patients in patients with rheumatoid arthritis. Materials and Method: This study was performed cross-sectionally with a descriptive-analytical approach on 123 patients with rheumatoid arthritis. After obtaining written consent, all individuals were undergoing lung ultrasound. The results of ultrasound to determine the diagnostic accuracy of this modality in ILD diagnosis, were compared with the findings of HRCT. In the next step, a checklist also included personal information such as gender, age, smoking and drug history for each patient. The collected data were analyzed after coding and logging into SPSS-21 statistical software and analyzed using appropriate statistical tests. Results: Evidence of ILD in HRCT study was observed in 37 subjects (about 30%). Sensitivity and specificity in ILD diagnosis were 64.8% and 60.47%, respectively. The positive predictive value (PPV), negative predictive value (NPV), positive odds ratio and negative odds ratio were estimated at 41.38%, 80%, 1.64, 0.58, respectively and diagnostic accuracy was 61.79%. Ultrasound sensitivity in both mild and moderate B-Line w