Sapporo Medical Journal aims to distribute and expand medical data to the World as well as build a supportive and vibrant community of researchers to connect and explore ideas by publishing articles related to all fields of medicine. Sapporo Medical Journal believes that quality and ethical research. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to:
Abstract : One in seven women are affected by postpartum depression which is an established clinical condition which affects women after childbirth. Pregnant women ought to be screened by employing a standardized tool evaluating them for depression and anxiety symptoms once through the pregnancy tenure to identify and manage the women at risk of developing postpartum depression. The purpose of the study was to assess the knowledge perception of postpartum depression among citizens of Al- Ahsa located in Eastern Province of Saudi Arabia. An online questionnaire oriented cross sectional study was executed over a period of one month. Study data was analyzed and evaluated in SPSS software version 21. A total of 446 participants responded the questionnaire, with a mean age of (35.2 ± 10.6 SD). Female participants (55.7%) were slightly more in number than the males. Most of the participants were married, employees, undergraduates and graduates. Regarding prevalence of Postpartum depression (PPD) most of them were unaware (60.4%) but majority identified symptoms of PPD correctly. Larger number of participants (74.3%) reflected that psychological intervention is effective in treating PPD. Half of them (54.8%.) did not have the idea about vitamins use in the treatment of PPD. Overall total of 60.51% participants answered the questionnaire correctly. Associations of the responses with independent variable were not statistically significant. It is concluded that Al-Ahsa inhabitants were capable of
Abstract : Colchicine is a medication used to treat gout and Behçet's disease. A rapid, stable and sensitive reversed phase liquid chromatography method coupled with MS/MS detector was developed and validated for determination of Colchicine in human plasma, Colchicine and internal standard (Colchicine-D3) were usefully extracted from human plasma samples by using liquid-liquid extraction technique. Validation parameter was carried out for the chromatographic method used for determining Colchicine in plasma including: accuracy, precision, linearity, selectivity, stability, calibration curve, recovery. The mobile phase consisting of (85% methanol: 15% Ammonium chloride), column ACE C8, (50 X 2.1) mm, 5 µm, flow rate was 0.4 ml/min, retention time was 0.44 minute for colchicine and Colchicine- D3, and the total run time was 0.8 minute. The lower limit of quantitation was 0.05 ng/mL, the calibration curve was linear (R2 = 0.9985) over the range of (0.05 – 4.00) ng/ml. The intra- and inter day precisions for quality control samples were < 10.0%, and the intra- and inter day accuracies were in the range of (89.33-106.33) %. However, the current LC/MS method of colchicine could be applied for pharmacokinetic study in human plasma.
Abstract : To reduce acute postoperative pain in major abdominal surgeries, patient-controlled epidural analgesia (PCEA) has been considered the gold standard. However, in recent years, its safety is being questioned as despite its low incidence rate of serious complications, these complications are often very dangerous nevertheless. On the other hand, for minimally invasive surgeries (MIS) with estimated reduced postoperative pain, intravenous patient-controlled analgesia (IV PCA) is seen as a possibly more effective alternative due to the autonomy and satisfaction given to the patient. A systematic review of previous RCTs and clinical trials of patients undergoing abdominal MIS was done to compare acute postoperative pain, length of hospital stay, time to first flatus, and incidence of postoperative nausea and vomiting (PONV) between PCEA and IV PCA. During movement, pain scores consistently showed a lower pain score in the PCEA group rather than the IV PCA group, because epidural analgesia with local anesthetics blocks non-nociceptive stimuli on top of nociceptive stimuli. Only 1 study showed > 0.1 day difference in length of stay after surgery. The IV PCA group took a longer time to first flatus and showed a higher percentage of patients experiencing PONV than in the PCEA group. This review showed that incidence of severe complications in PCEA proves to be low and is therefore the best method to reduce postoperative pain in abdominal MIS.
Abstract : The Jakarta Health Office initiated the “Knock on Doors, Serve with Heart” (hereinafter called KPLDH standing for Ketuk Pintu Layani Dengan Hati) program with the main objective of serving the community with a heart to the fullest and preventing sick people from becoming poor. KPLDH is an effort by the government to bring health services closer to the community, especially in the promotional and preventive fields. This study aims to develop a construction variable model for the KPLDH Program Performance index to measure the effectiveness of the KPLDH public policy program in Jakarta using the Baldrige Framework approach. This evaluation implementation research aims to determine the level of success of a program or to determine the effectiveness of program implementation. This research was conducted in mix-method. The study was followed by 44 sub-district health centers in Jakarta with a total of 308 respondents who submitted the KPLDH Program Performance Index assessment using the Baldrige assessment method approach. The results of the KPLDH Program Performance Index assessment are 82,16% with the predicate level of Benchmark Leader at the excellent level. These results indicate the implementation of the program with a systematic, effective, and responsive approach to the derivatives of the policies that have been determined, and good to excellent integration is proven by analysis, learning and sharing of organizational best practices as a key management strategy.
Abstract : Hypercholesterolemia is a primary risk factor for cardiovascular disease. One of the natural food that can lower cholesterol is Spirulina. Spirulina contains several active ingredients, especially phycocyanin and β-carotene, which have antioxidant activity and anti-inflammatory activity. Spirulina will be mixed with Yogurt that can lower cholesterol as well. The purpose of this study was to evaluate the effect of Spirulina Yogurt (Spirulina platensis) on total blood cholesterol levels in patients with hypercholesterolemia. The study was used as a pretest-posttest randomized control trial experimental with a control group design. The population in this study was hypercholesterolemia patients (total cholesterol ≥200 mg/dl). Samples were taken by purposive sampling, a sample of 8 people in the treatment group, and 8 people in the control group. The treatment group was given Spirulina Yogurt (1gram/200ml/day), while the control group was given Yogurt (200ml/day) for 14 days. The results showed that there was no significant change in the value of the control group (p=0,074>0,05), but there was a significant change in the treatment group (p=0,017<0,05). There was no significant difference in total cholesterol between the treatment and control groups (p = 0,812>0,05). Therefore, further research is needed to determine the effective dose and period time of the study and the process of making Spirulina yogurt properly so that it can be effective in lowering cholesterol.