Sapporo Medical Journal aims to distribute and expand medical data to the World as well as build a supportive and vibrant community of researchers to connect and explore ideas by publishing articles related to all fields of medicine. Sapporo Medical Journal believes that quality and ethical research. The journal seeks to publish original research articles that are hypothetical and theoretical in its nature and that provide exploratory insights in the following fields but not limited to:
Abstract : Intradialytic parenteral nutrition is a complementary route of nutritional administration to treat the 5th renal stage hemodialytic malnourished cases. Multiple clinical studies have elucidated contradictory suggestions regarding Intradialytic parenteral nutrition efficacy and validity. This review displays a comprehensive assessment for the use of Intradialytic parenteral nutrition, the controversy over indications, benefits, and risks, as well as summarizes the current recommendations for Intradialytic parenteral nutrition indication and variable health outcomes.
Abstract : The height of prenatal is a risk factor for the Length of newborn infants. Other risks that may affect the Length of a newborn infant are the Body Mass Index (BMI), the age of prenatal during their early pregnancy, the low intake of energy and protein, and the history of chronic energy deficiency. The goal of the research is to determine the various factors related to the Length of newborn infants. The results were expected to provide the determinants of newborn infant length, which can be predicted before pregnancy until the date of labor. The result can be used as a basis to determine the appropriate intervention in the prevention of stunted children. The study design is cross-sectional, with a total sample of 46 prenatal. The Spearman correlation test showed that only three variables could be included in the prediction models with p < 0.25. It was the height of mothers before pregnancy (RS = -0,027; p=0,060), the energy intake of pregnant women with in the last month pregnancy (RS: 0,553; p=0,00), and protein intake of pregnant women with in the last month of pregnancy (RS=0,42; p=0,002). Prediction model produces in Multiple Linear Regression Line Equation is the length of newborn infant = 57.268 - Protein intake 0,075x average - 0.079 x height before pregnancy + 0.002 x intake of energy last one month + 0.090 x intake Protein 1 last month. It is recommended that pregnant women with short stature need more energy intake during pregnancy, especially in the last month of pr
Abstract : Objectives: To determine the incidence rate of childhood cancer and its trends in Thi-Qar, Iraq during 2012-2018. Methods: This registry based descriptive study included children aged 0-14 years with newly diagnosed primary cancers in Thi-Qar during 2012-2018. The types of cancers were classified according to the ICCC-3. The overall and specific incidence rates by age and sex were calculated per 100,000 children. JoinPoint software was used to examine the magnitude, direction, and change of incidence trends. Results: For the years 2012-2018, 633 new cases [349 (55.1%) boys and 284 (44.9%) girls, with ratio of 1.23:1] were registered among children aged <15 years. Children aged ≤4 years accounted for 41.5% of patients. The average annual incidence rate was 11.14/100,000 (ASIR was 12.00/100,000 children per year). The incidence rate increased from 7.61/100,000 in 2012 to 14.62/100,000 in 2018 at an annual percent change (APC) of 6.9%. Boys showed higher incidence rate than girls (11.93 vs. 10.30/100,000, p-value=0.02). The incidence rate was highest for children ≤4 years. Leukemia was the most common type of cancer accounting for 33.02%/%, followed by CNS neoplasms (15.48%), and lymphomas (14.53%). Conclusion: The incidence rate of childhood cancer in Th-Qar is increasing with time. It is comparable to that reported for developing countries but there is a shift of cancer types' distribution similar to that in developed countries.
Abstract : Background: several factors are implicated in the occurrence of cancer basing on the degree of DNA damage to which, in turn, is equivalent to the extent of reactive oxygen and nitrogen stresses, 8-Hydroxydeoxyguanosine (8- OHdG) is consider as a marker of oxidative stress in DNA molecule . Objective: This research was conducted to assess serum markers of protein oxidation, DNA damage, and lipid peroxidation levels in ovarian cancer. Patients and methods. The present study is composed of 85 women (mean age = 62.03±12.4 yrs) with clinically and pathologically confirmed ovarian cancer and 65 healthy women as a control group (mean age = 61±12.1 yrs). The measured biochemical parameters included: the level of serum protein oxidation, DNA damage, and lipid peroxidation Results: The results demonstrated significantly high values of 8-OHdG (p<0.0001) and significantly high (p<0.001, p<0.002)values in advanced oxidation protein products (AOPPs) & 3-Nitrotyrosine (3-NT) in ovarian cancer in comparison with control group. There were also significantly high (p<0.05, p<0.001) values of sera, 4-hydroxynonenal 4-(HNE) and (8-isoprostaglandin F2alpha(8-PGF) in women ovarian cancer in comparison with control group. Conclusion: Assessment marker of, DNA damage, lipid peroxidation and protein oxidation May serve as prognostic tools in Ovarian carcinoma and the role of oxidative stress as a carcinogenic factor in ovarian cancer pathogenesis.
Abstract : Kappaphycus alverazii is commonly cultured in Vietnam and mainly contains carrageenan that is useful in food, beverages, functional food, and pharmaceuticals. The study focused on the evaluation for the semi-chronic toxicity of carrageenan on guinea pig (Cavia porcellus) for 42 days, inside, 21 first days (experiment), and 21 next days (recovery). Carrageenan extracting from Kappaphycus alverazii by the enzyme-assisted method and the purification of carrageenan by using 96 % ethanol. Mice were observed on clinical, weighed, evaluated on the chemical composition of urine and blood, and sliced cells (liver, kidney, and spleen). The results showed that carrageenan extracting by the enzyme-assisted method and purifying by 96 % ethanol was non-toxicity. Carrageenan did not impact the liver, kidney, and spleen of experimental mice, exhibited on the microscopy figure. The fresh weight of the liver, kidney, and spleen increased according to adulthood time, suitable for the weighing increase of mice. The chemical composition of urine and blood was a non-significant difference between mice groups drinking carrageenan and the control group, except for mononuclear leukocyte (M) (MPV) (p<0.05).