Sapporo Medical Journal

Abstract : Background: several factors are implicated in the occurrence of cancer basing on the degree of DNA damage to which, in turn, is equivalent to the extent of reactive oxygen and nitrogen stresses, 8-Hydroxydeoxyguanosine (8- OHdG) is consider as a marker of oxidative stress in DNA molecule . Objective: This research was conducted to assess serum markers of protein oxidation, DNA damage, and lipid peroxidation levels in ovarian cancer. Patients and methods. The present study is composed of 85 women (mean age = 62.03±12.4 yrs) with clinically and pathologically confirmed ovarian cancer and 65 healthy women as a control group (mean age = 61±12.1 yrs). The measured biochemical parameters included: the level of serum protein oxidation, DNA damage, and lipid peroxidation Results: The results demonstrated significantly high values of 8-OHdG (p<0.0001) and significantly high (p<0.001, p<0.002)values in advanced oxidation protein products (AOPPs) & 3-Nitrotyrosine (3-NT) in ovarian cancer in comparison with control group. There were also significantly high (p<0.05, p<0.001) values of sera, 4-hydroxynonenal 4-(HNE) and (8-isoprostaglandin F2alpha(8-PGF) in women ovarian cancer in comparison with control group. Conclusion: Assessment marker of, DNA damage, lipid peroxidation and protein oxidation May serve as prognostic tools in Ovarian carcinoma and the role of oxidative stress as a carcinogenic factor in ovarian cancer pathogenesis.

Abstract : Kappaphycus alverazii is commonly cultured in Vietnam and mainly contains carrageenan that is useful in food, beverages, functional food, and pharmaceuticals. The study focused on the evaluation for the semi-chronic toxicity of carrageenan on guinea pig (Cavia porcellus) for 42 days, inside, 21 first days (experiment), and 21 next days (recovery). Carrageenan extracting from Kappaphycus alverazii by the enzyme-assisted method and the purification of carrageenan by using 96 % ethanol. Mice were observed on clinical, weighed, evaluated on the chemical composition of urine and blood, and sliced cells (liver, kidney, and spleen). The results showed that carrageenan extracting by the enzyme-assisted method and purifying by 96 % ethanol was non-toxicity. Carrageenan did not impact the liver, kidney, and spleen of experimental mice, exhibited on the microscopy figure. The fresh weight of the liver, kidney, and spleen increased according to adulthood time, suitable for the weighing increase of mice. The chemical composition of urine and blood was a non-significant difference between mice groups drinking carrageenan and the control group, except for mononuclear leukocyte (M) (MPV) (p<0.05).

Abstract : Background: The newly emerging covid-19 pandemic has imposed an undeniable burden on the global health care systems and human well-being. Objective: To holistically evaluate the perception and knowledge of radiology team members as regards COVID-19 infection and its related aspects. Methodology: A cross-sectional anonymous questionnaire-based survey was conducted among radiology teams within the Eastern Province of Saudi Arabia. It targeted both radiologist and radiology technicians. Results: one hundred fifty-four radiology team members participated in this study. They were 88 radiologists and 66 technicians. Sixty-two radiologists (70%) had a good knowledge about the new Saudi Ministry of Health (MOH) guidelines for the radiology department teams during the covid-19 pandemic. Their overall perception and practice regarding the protective measures was very high (96.8%). Conclusion: Radiology team members within the Eastern Province area were highly acquainted with the MOH guidelines for dealing with covid-19 pandemic. They are also fully oriented with the self-precautionary measures during the pandemic. Although the participants’ number is slightly limited, it may highlight the need for further studies with higher participants’ number to give a realistic view of the radiologists and their team when dealing with biological hazards such as this pandemic.

Abstract : Introduction: Patients with coronavirus 19 (COVID 19) presented with mesenteric venous thrombosis (MVT). Methods: This study included 10 patients presented with acute abdomen who were diagnosed with MVT on contrast enhanced CT of the abdomen. Diagnosis of COVID 19 was confirmed by PCR on nasal and orpharyngeal swab in 8 cases while the other two cases with negative PCR were diagnosed by high resolution chest CT. All cases were managed with abdominal exploration except for one case with splenic infarction which was managed conservatively. All cases received therapeutic dose of low molecular weight heparin postoperatively. Results: In our study two cases out of nine required re-exploration and re-resection of the gangrenous bowel segment and another two cases require mechanical ventilation because of chest complication. Conclusion: The best current strategies for confronting such complication in COVID-19 are prophylaxis with low-molecular-weight heparin and treatment with full-dose low-molecular-weight heparin with monitoring of anti-Factor Xa if available; however there is no evidence to support thus result.

Abstract : Abstract: Public health concerns have been raised about the possibility that exposure to radiofrequency electromagnetic fields from cell phones could affect the overall health. Objectives: to determine the perception of university students regarding Mobile phone health hazards, and find out their actual practice of usage. Study design: A cross sectional study was conducted in Minia University. Methods: The study participants were university students from different faculties. A total of 765 participants answered the questionnaire. Results: Most of participants (72.1% of males and 86.9% of females have at least one mobile phone, 77.2% of males and 56.5% of females using mobile phone for 5-10 years. Right ear (45.6%) was preferred. (75.5%) of females locate the mobile in the bag while 82.6% of males locate it in their pocket. Majority of males (99.2%) and females (99.5%) were aware about health hazards of mobile phone. Most of participants agreed that mobile phone usage can cause headache (87.8%), sleep disturbance (63%), and loss of mental attention (58.7%). Conclusions: the authors found that most of the participants used the mobile phone for 5-10 years. Right ear was preferred than left ear. Majority of the students were aware about health hazards of mobile phone. Most of them agreed that the mobile phone usage can cause health hazards.