Sapporo Medical Journal

Abstract : Relationship between Covid19 & androgen receptor

Abstract : Rheumatoid arthritis (RA) and systemic lupus erythematosus are considered chronic inflammatory autoimmune diseases with unknown etiology and systemic involvement.Both PLR and NLR are associated with the inflammatory status. Based on this, wehypothesized that both NLR and PLR may also be correlated with the disease activity of RA and SLE

Abstract : In rheumatoid arthritis patients the risk of cardiovascular affection is 2–3 times higher than the general population, with increased morbidity and mortality. This is due to increase in the traditional and nontraditional risk factors. The aim of this study is to determine the cardiovascular risk in patients with RA using four established CV risk algorithms Framingham Risk Score (FRS), Systematic Coronary Risk Evaluation Score (SCORE], Reynolds Risk Score (RRS), Q II Risk Score and there relation with serum levels of leptin and interleukin-6 (IL-6). Methods:Cross sectional study was conducted during the period between December 2018 and June 2019 Sixty seven RA patients were enrolled in this study. The 10-year CVR for RA patients were calculated using FRS, SCORE, RRS and Q II Risk Score. Serum leptin and IL-6 were estimated. Results:The results showed a significant difference between higher leptin values and disease activity, obesity, positive RF and longer disease duration, On the other hand, we found a significant difference between higher IL-6 values and disease activity, and hypertriglyceridemia. As regarding correlations of IL-6 and Leptin with different cardiovascular scores, there were no significant correlations with exception of moderate significant correlation between IL-6 and RRS (r= 0.42, P< 0.001). Conclusion:We found no correlation between CVR scores and leptin or IL-6 except for RRS and IL-6, therefore new models of CVD risk prediction incorporating RA specific

Abstract : Studies on the degree of adherence to folic corrosive (FA) and elements related were limited in a wide assortment and affirmed inconsistency in the indistinguishable area and among uncommon populaces. by means of recognizing those components, there could be a chance to improve the consistence and afterward decline in the commonness of undesirable outcomes as NTD. The medicinal services organizations have a critical job in this adherence. A go-sectional see that utilizes a multistage examining approach transformed into utilized. It becomes directed among various number one medicinal services habitats in Al-Ahsa town. The example size transformed into 176 pregnant women dependent on the prevalence of acknowledgment concerning FA consumption during being pregnant. It transformed into 160 above all else, be that as it may, 10% of victims were presented so one can control the dropouts. the predominance of utilization of FA among pregnant in their first trimester transformed into agreeable (87%). least complex 2% of pregnant have a past little child with NTD. by methods for surveying the FA adherence degree, we found that lone 15% are particularly disciple. A not strange thought process (71%) of low adherence changed into distraction auxiliary to dealing with others watched by means of being a working mother and ignorance of FA essentialness. 13% of pregnant did now not take FA in any regard. the principle intentions in the rear of the non-utilization of FA as member referred to th

Abstract : Rising diseases have caused a giant impact on humankind as a result of their unexpected occasions at a sporadic time and spot. Advancement of viral illnesses happens when etiological diseases cross their run of the mill nooks or edges. These contaminations have mixed open care as a result of the advancement on various stages, especially media. The clarification behind creation such perilous care is the approaching high distressingness and mortality brought about by these diseases. Though most of them are non-immune response preventable, early clinical finding and palliative thought with extraordinary ailment control practices can check scenes and pandemics.