Sapporo Medical Journal

Abstract : Genetic and population-statistical results of association of alleles and genotypes of rs1805010 lle50Val polymorphism of IL4RA gene are analyzed, in 75 patients with atopic bronchial asthma and 25 healthy children, depending on the article, type of inheritance, homozygous or heterozygous genotype. The results of the study showed that in general the increased risk of developing allergic asthma in children is determined in carriers of homozygous genotype A/A polymorphism rs1805010 lle50Val gene IL4RA, because in patients with asthma, it occurs 4.34 times more often than in almost healthy children (OR = 6.10; 95% CI [1.33-27.93]; p <0.003), than in almost healthy children. The association of the lle50Val polymorphism of the IL4RA gene in rs1805010 with the development of bronchial asthma by us among girls has not been established, , while the homozygous genotype G / G is more common (0.368) among boys who have, accordingly, a reduced risk of developing bronchial asthma (OR = 0.34; 95% CI [0.16-0.73]; p = 0.003).

Abstract : Food processing with deep fat frying method with palm oil has been frequently made either by restaurants, caterings, or food industries in Indonesia. It has been identified that the frying process with high temperature and long frying duration cause of the oil damage. The objective of this review is to describe the chemical change in palm oil during the frying process with deep fat frying method and to evaluate the results of oxidation, hydrolysis, and polymerization reactions during the frying process. The frying temperature between 150-250oC, frying duration until 48-50 hours, the repeated oil use caused the decomposition of some triglycerides, the composition change of saturated fatty acids (SFA), mono-unsaturated fatty acids (MUFA), poly-unsaturated fatty acids (PUFA), and the formation of aldehyde compound, short chain fatty acids, ketone compound categorized as volatile and non-volatile compounds. The evaluation of the oil quality during the frying process taking into account the peroxide, iodine, para-anisidine, free fatty acid values and the percentage of total polar compounds is also discussed in this review. The toxic contaminant compounds due to high temperature frying (in average 180oC) have been formed. They are trans-fatty acids i.e. elaidic (C18:1,9t) and trans (C18:2,9C12t/9t12c). Glycidyl esters compound are formed in palm oil during temperature deodorization process of >230oC. The contaminant concentration reduces during the frying which are observed from so

Abstract : A spectrophotometric analysis for valuing microgram quantities of Chlorpromazine hydrochloride drug in aqueous solution is defined that is simple, fast, and sensitive. The process is based on the formation of an intense red colored substance with maximum absorption at 530 nm from a transition metal complex between Chlorpromazine hydrochloride and Lead (IV) oxide (metal) in the existence of hydrochloride acid. With a Molar absorptivity of 2.9394 x104 l.mol-1.cm-1 and a Sandells sensitivity 0.014μg.Cm-2, Beer's Law is followed over a concentration range of ( 1- 20) μg.ml-2. The planned process has been effectively useful for assessment of Chlorpromazine hydrochloride in pharmaceutical preparations (Largactil drug)and bulk drug, and The optimum conditions for all colour production are defined. In this methodology, shared excipients and additives had no effect.

Abstract : Background: The global population is shifting toward a more advanced age. It is expected that the global population aged more than 60 years will reach 1.4 billion by the year 2030. Therefore, in this study, the functional health among Saudi community-dwelling older adults in Makkah province was assessed. Methodology: This cross-sectional study was conducted from July 2019 to June 2020 in Makkah province, Kingdom of Saudi Arabia. A total of 328 participants completed our survey. Qualitative variables were described in frequencies and percentages, while quantitative data were expressed in means ± standard deviations. In addition, P-values were calculated using the Pearson chi-square test to define the significance of the results. Result: Activity of daily living (ADL) score was significantly associated with older age, being divorced/separated/widowed, and the presence of more than three comorbidities (P < 0.001). Participants with a low ADL score were more likely to have never left home in the last month, had a fall in the last year, and have an inadequate income (P < 0.001). In addition, participants who were satisfied and happy with their life had a better average ADL score (P < 0.001). Conclusion: In conclusion, age, marital status, number of comorbidities, lack of satisfaction in life, falls, and income had an important effect on the prevalence of functional disability. Most of these factors are modifiable; therefore, practitioners should be aware of these factors to

Abstract : Background : Bilateral cleft lip nose deformity is a multi-factorial and complex deformity. Bilateral cleft lip repair presented one of the greatest challenges for plastic surgeons. Although the nasal contour in bilateral cleft lip patients is relatively symmetric compared with that in unilateral cleft lip patients, the deformities themselves are more severe. Open rhinoplasty is performed secondarily using auricular cartilage grafts. This approach has a purpose to know the application of Sun Shield Cartilage Graft for Correction of Secondary Bilateral Cleft Lip Nasal Deformities. Methods : A 8-years-old child woman with chief complaint of deformities on her lip and nasal. With secondary Bilateral Cleft Lip Nasal Deformities the patient underwent columella lengthening and Sun Shield Cartilage grafting with open rhinoplasty. Result : The nasal profiles were improved to the patients. The columellar and nostril heights were increased. The columella and the nasal dorsum were lengthened. Conclusion: Based on clinical results indicate that “SUN SHIELD” Cartilage Graft with open rhinoplasty is effective for correction of secondary Bilateral Cleft Lip Nasal Deformities.