Sapporo Medical Journal

Abstract : Background: AML is a heterogeneous haematological malignancy , it is the most common acute leukemia in adults. FLT3 is the most common molecular aberration in AML , belongs to the group of class III receptor tyrosine kinases (RTKs) which also include the receptors c-kit and c-fms and PDGFR, mutated in more than one third of the AML cases, subdivided into two major classes :internal tandem duplication(ITD) and tyrosine kinase domain(TKD).FLT3/ITD is associated with higher probability of relapse and worse outcome, and however, there is controversy about its impact on the induction outcome. Objectives: 1.The prevalence of the FLT3/ITD mutation in Iraqi adult de-novo AML patients 2. The effect of the FLT3/ITD mutation on the remission induction outcome (CR rate) 3. The association of this gene with the laboratory tests(WBC, Hb ,PLT ,BM blast %) Patients and methods: This Cohort study comprised 41 adult de-novo AML patients, admitted in Baghdad medical city complex from Jan.2018 to Dec.2019, Each patient was investigated by complete blood count and differential, bone marrow aspiration and biopsy as well as immunophenotyping to confirm the diagnosis of AML.All of them had received the standard (3+7 ) protocol.FLT3 gene was screened by expert genetist using conventional PCR technology with special primers in teaching laboratories/molecular unit in Baghdad medical city complex, just at time of diagnosis . The post-induction assessment was done by examination of bone marrow

Abstract : Abstract : Human Immunodeficiency Virus (HIV) infection can be caused damage to the immune system and leading to immunocompromised conditions, making the person more likely to get other infections. Myiasis is a maggots infestation in the human body, in immunocompromised conditions, it can lead to severe conditions and cause death. Human cerebral myiasis in HIV patients is a rare condition. HIV Infection and type 2 Diabetes Mellitus (DM) play a major role in immune system dysregulation which leads to immunocompromise. Hereby, we report those case with its management.

Abstract : Background: Colorectal cancer constituting one of the most frequently occurring malignancies.Previous studies exhibiting the cells of the host signaling manipulation by the bacteria, where chronic or carriage of the bacterial infection can triggering the cancer development among the predisposed genetically persons. Justification: Usage of such triage link can solve many probabilities in studying the role of bacterial risk in cancer. Aims: Studying the Triage of Colorectal Cancer ,Lymphocytic Cell Infiltration , And Bacterial Infection Method: A 76 cases compared with nearly similar number of control by selecting their histopathologic specimens most of the control where excluded because of the insufficient sample size.Comparison done in Thi-Qar province- Southern of Iraq, extended from September 2020 the end of June 2021. Bacterial DNA was detected by PCR technique, and the PCR results were linked with demographic parameters such as age and gender. The data were examined by SPSS (26), P value <0.05consider significant. Result: Universal bacterial primer gave a positive results in 58(57.4%) of cases and only 8 (7.8%) cases of this where positive for bacterial primers. Most cases of colorectal cancer grade were grade II -A 36.8% followed by grade II-B 19.7%. The distribution of bacterial DNA universal primer was highly amounted in Stage III (56.8%) followed by Stage II, and the bacterial DNA were also detected in higher proportion in stage III of colorectal cancer followed by

Abstract : Conjoined twins are a rare case. Thoraco-omphalopagus was one of the most common types of conjoined twins. The management of thoracic defects presents a great challenge, especially since no standard procedures for chest reconstructions are available in the center. In this case report, we describe the successful reconstruction of a thoracic defect in thoraco-omphalopagus 17 months years old conjoined twin with titanium mini-plate and wire stabilization. The twins are now 2.5 years old, are healthy and have normal growth, and are under follow-up.

Abstract : Transurethral resection of the prostate (TURP) is currently the gold standard procedure for benign prostate hyperplasia (BPH). It may lead to various complications, such as urinary tract infection (UTI). Antibiotic prophylaxis use for TURP in the world has been studied, especially in the high-risk case. We aimed to evaluate the effectiveness of antibiotic prophylaxis in reducing bacteriuria and sepsis incidences on post-TURP patients. A systematic search was conducted in PUBMED, SCIENCE-DIRECT databases. The eligible analysis and article selection followed The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) protocol, analysis of bias used Cochrane Risk of Bias Tools, each was done by 2 independent reviewers. Five RCT articles are declared eligible and involved 872 patients. Forest plot shows data heterogeneity from post-TURP bacteriuria incidence, and there is significant difference between antibiotic prophylaxis and placebo/no therapy (OR=0.38, 95% CI=0.17 – 0.88; p = 0.02). The Forest plot shows data homogeneity from post-TURP sepsis incidence, and there is no significant difference between antibiotic prophylaxis and placebo/no therapy (OR=0.64, 95% CI=0.09 – 4.53; p = 0.66). Post-TURP bacteriuria incidence in patients administered with antibiotic prophylaxis is lower than placebo/no therapy, but post-TURP sepsis incidence in patients administered with antibiotic prophylaxis is the same as placebo/no therapy.